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Adenosine Dialdehyde (ADOX)

Name: Adenosine Dialdehyde (ADOX)
Brand: TargetMol
SKU: T22231
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22231Cas No. 34240-05-6

Alias Periodate-oxidized adenosine, Adenox, Adenosinedialdehyde, Adenosine, periodate oxidized

Adenosine Dialdehyde (Periodate-oxidized adenosine) is a purine nucleoside analogue. Adenosine Dialdehyde is a potent inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) (Ki=3.3 nM). Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo.

Adenosine Dialdehyde (ADOX)

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Purity: 95%

Catalog No. T22231Alias Periodate-oxidized adenosine, Adenox, Adenosinedialdehyde, Adenosine, periodate oxidizedCas No. 34240-05-6

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$50	In Stock	In Stock
10 mg	$64	In Stock	In Stock
25 mg	$95	In Stock	In Stock
50 mg	$166	In Stock	In Stock
100 mg	$249	In Stock	In Stock
200 mg	$373	-	In Stock
500 mg	$628	-	In Stock
1 mL x 10 mM (in DMSO)	$55	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:95%

Appearance:Solid

Color:Yellow

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COA

Product Introduction

Bioactivity

Description	Adenosine Dialdehyde (Periodate-oxidized adenosine) is a purine nucleoside analogue. Adenosine Dialdehyde is a potent inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) (Ki=3.3 nM). Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo.
In vitro	Adenosine dialdehyde suppresses MNB cell replication in tissue culture (1.5 μM, 50% inhibition) [1].
In vivo	Adenosine dialdehyde (subcutaneous injection; 1.5-2.5 mg/kg; two 7-day periods interspersed by a 7-day drug free interval( minipump infusion))increases mean life span 80% in diluent treated controls (controls, 21.3 days; AD treated 38.4 days) in mice. Adenosine dialdehyde (subcutaneous injection; 1.5-2.5 mg/kg; infused over a 7-day period ( minipump infusion)) significantly increases the mean life span of tumor bearing mice from 20.9 days in diluent treated controls to 35.3 days in AD treated animals. Adenosine dialdehyde (subcutaneous injection; 2-3 mg/kg; infused over a 7-day period ( minipump infusion)) does not exhibit any hematopoietic toxicity in mice, and it can significantly suppress murine neuroblastoma tumor growth with little systemic toxicity[2].
Synonyms	Periodate-oxidized adenosine, Adenox, Adenosinedialdehyde, Adenosine, periodate oxidized

Chemical Properties

Molecular Weight	265.23
Formula	C₁₀H₁₁N₅O₄
Cas No.	34240-05-6
Smiles	C(OC(CO)C=O)(C=O)N1C=2C(N=C1)=C(N)N=CN2
Relative Density.	1.69 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 102 mg/mL (384.57 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.54 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7703 mL	18.8516 mL	37.7031 mL	188.5156 mL
5 mM	0.7541 mL	3.7703 mL	7.5406 mL	37.7031 mL
10 mM	0.3770 mL	1.8852 mL	3.7703 mL	18.8516 mL
20 mM	0.1885 mL	0.9426 mL	1.8852 mL	9.4258 mL
50 mM	0.0754 mL	0.3770 mL	0.7541 mL	3.7703 mL
100 mM	0.0377 mL	0.1885 mL	0.3770 mL	1.8852 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc