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Adenosine Dialdehyde (ADOX)

Name: Adenosine Dialdehyde (ADOX)
Brand: TargetMol
SKU: T22231
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T22231Cas No. 34240-05-6

Alias Periodate-oxidized adenosine, Adenox, Adenosinedialdehyde, Adenosine, periodate oxidized

Adenosine Dialdehyde (Periodate-oxidized adenosine) is a purine nucleoside analogue. Adenosine Dialdehyde is a potent inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) (Ki=3.3 nM). Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo.

Adenosine Dialdehyde (ADOX)

🥰Excellent

Purity: 95%

Catalog No. T22231Alias Periodate-oxidized adenosine, Adenox, Adenosinedialdehyde, Adenosine, periodate oxidizedCas No. 34240-05-6

Pack Size	Price	Availability
5 mg	$50	In Stock
10 mg	$64	In Stock
25 mg	$95	In Stock
50 mg	$166	In Stock
100 mg	$249	In Stock
200 mg	$373	In Stock
500 mg	$628	In Stock
1 mL x 10 mM (in DMSO)	$55	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:95%

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Product Introduction

Bioactivity

Description	Adenosine Dialdehyde (Periodate-oxidized adenosine) is a purine nucleoside analogue. Adenosine Dialdehyde is a potent inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) (Ki=3.3 nM). Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo.
In vitro	Adenosine dialdehyde suppresses MNB cell replication in tissue culture (1.5 μM, 50% inhibition) [1].
In vivo	Adenosine dialdehyde (subcutaneous injection; 1.5-2.5 mg/kg; two 7-day periods interspersed by a 7-day drug free interval( minipump infusion))increases mean life span 80% in diluent treated controls (controls, 21.3 days; AD treated 38.4 days) in mice. Adenosine dialdehyde (subcutaneous injection; 1.5-2.5 mg/kg; infused over a 7-day period ( minipump infusion)) significantly increases the mean life span of tumor bearing mice from 20.9 days in diluent treated controls to 35.3 days in AD treated animals. Adenosine dialdehyde (subcutaneous injection; 2-3 mg/kg; infused over a 7-day period ( minipump infusion)) does not exhibit any hematopoietic toxicity in mice, and it can significantly suppress murine neuroblastoma tumor growth with little systemic toxicity[2].
Synonyms	Periodate-oxidized adenosine, Adenox, Adenosinedialdehyde, Adenosine, periodate oxidized

Chemical Properties

Molecular Weight	265.23
Formula	C₁₀H₁₁N₅O₄
Cas No.	34240-05-6
Smiles	C(OC(CO)C=O)(C=O)N1C=2C(N=C1)=C(N)N=CN2
Relative Density.	1.69 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (169.66 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.54 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7703 mL	18.8516 mL	37.7031 mL	188.5156 mL
5 mM	0.7541 mL	3.7703 mL	7.5406 mL	37.7031 mL
10 mM	0.3770 mL	1.8852 mL	3.7703 mL	18.8516 mL
20 mM	0.1885 mL	0.9426 mL	1.8852 mL	9.4258 mL
50 mM	0.0754 mL	0.3770 mL	0.7541 mL	3.7703 mL
100 mM	0.0377 mL	0.1885 mL	0.3770 mL	1.8852 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc