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Valinomycin

Catalog No. TP1072 CAS 2001-95-8

Synonyms: NSC 122023

Valinomycin (NSC-122023) is a cyclic depsipeptide antibiotic and a potassium-specific ionophore.Valinomycin induces PINK1 activation and promotes Parkin phosphorylation at Ser65.

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Valinomycin, CAS 2001-95-8

Pack Size	Availability	Price/USD	Quantity
2 mg	In stock	$ 29.00
1 mL * 10 mM (in DMSO)	In stock	$ 199.00

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Purity: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Valinomycin (NSC-122023) is a cyclic depsipeptide antibiotic and a potassium-specific ionophore.Valinomycin induces PINK1 activation and promotes Parkin phosphorylation at Ser65.

In vivo

Valinomycin is irritating in contact with eyes and skin. Inhalation of Valinomycin can cause respiratory disturbances and even loss of consciousness. The median lethal dose (LD50) of Valinomycin in mice and rabbits was 2.5 mg/kg and 5 mg/kg, respectively. Valinomycin also has various chronic effects, including central and peripheral nervous system damage, eye damage, lens damage, and corneal damage [3].

Synonyms	NSC 122023
Molecular Weight	1111.32
Formula	C54H90N6O18
CAS No.	2001-95-8

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 40 mg/mL (36 mM), Sonification is recommended.

DMSO: 20 mg/mL (18 mM), Sonification is recommended.

References and Literature

1. Kondapalli C, et al. PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65. Open Biol. 2012 May;2(5):120080. 2. Abdalah R1, Wei L, Francis K, Yu SP. Valinomycin-induced apoptosis in Chinese hamster ovary cells. Neurosci Lett. 2006 Sep 11;405(1-2):68-73. Epub 2006 Jul 20. 3. Kroteń MA, Bartoszewicz M, Swiecicka I. Cereulide and valinomycin, two important natural dodecadepsipeptides with ionophoretic activities. Pol J Microbiol. 2010;59(1):3-10.

Citations

1. Chen X C, Tang G X, Luo W H, et al. Monitoring and Modulating mtDNA G-Quadruplex Dynamics Reveal Its Close Relationship to Cell Glycolysis. Journal of the American Chemical Society. 2021

Related compound libraries

This product is contained In the following compound libraries：

Peptide Compound Library Microbial Natural Product Library Bioactive Compound Library Anti-Infection Compound Library Anti-Pancreatic Cancer Compound Library Anti-Ovarian Cancer Compound Library Anti-Bacterial Compound Library Anti-Prostate Cancer Compound Library Apoptosis Compound Library Glycolysis Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Valinomycin 2001-95-8 Apoptosis Autophagy Microbiology/Virology PI3K/Akt/mTOR signaling Antibiotic Antibacterial PTEN NSC122023 Bacterial Inhibitor inhibit NSC 122023 NSC-122023 inhibitor

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