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Terodiline hydrochloride

Catalog No. T13129   CAS 7082-21-5

Terodiline hydrochloride is an antagonist of M1-selective muscarinic receptor (mAChR)(Kbs of 15, 160, 280, and 198 nM in rabbit vas deferens (M1), atria (M2), bladder (M3) and ileal muscle (M3), respectively).

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Terodiline hydrochloride Chemical Structure
Terodiline hydrochloride, CAS 7082-21-5
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25 mg 6-8 weeks $ 1,220.00
50 mg 6-8 weeks $ 1,590.00
100 mg 6-8 weeks $ 2,430.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Terodiline hydrochloride is an antagonist of M1-selective muscarinic receptor (mAChR)(Kbs of 15, 160, 280, and 198 nM in rabbit vas deferens (M1), atria (M2), bladder (M3) and ileal muscle (M3), respectively).
In vivo Terodiline treatment with 80 mg/kg; S.C. is equipotent in inhibiting intravesical bladder pressure and carbachol-induced salivary secretion with ID50 of 24 and 35 mg/kg, respectively, and in increasing pupil diameter with ED50 of 59 mg/kg.
Molecular Weight 317.9
Formula C20H28ClN
CAS No. 7082-21-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Noronha-Blob L, et al. (+/-)-Terodiline: an M1-selective muscarinic receptor antagonist. In vivo effects at muscarinic receptors mediating urinary bladder contraction, mydriasis and salivary secretion. Eur J Pharmacol. 1991 Aug 29;201(2-3):135-42.

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Keywords

Terodiline hydrochloride 7082-21-5 Neuroscience AChR Terodiline Hydrochloride inhibitor inhibit

 

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