Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sulfo-SMCC sodium, a widely utilized non-cleavable, hetero-bifunctional crosslinker for antibody-drug conjugates (ADCs), features both N-hydroxysuccinimide (NHS) ester and maleimide groups. These functionalities enable it to specifically react with primary amines and sulfhydryl groups, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 41.00 | |
25 mg | In stock | $ 58.00 | |
50 mg | In stock | $ 74.00 | |
100 mg | In stock | $ 97.00 | |
200 mg | In stock | $ 162.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Sulfo-SMCC sodium, a widely utilized non-cleavable, hetero-bifunctional crosslinker for antibody-drug conjugates (ADCs), features both N-hydroxysuccinimide (NHS) ester and maleimide groups. These functionalities enable it to specifically react with primary amines and sulfhydryl groups, respectively. |
In vitro | Sulfo-SMCC, a crosslinker featuring a maleimide group and an N-hydroxysuccinimide ester, is designed to attach to sulfhydryl groups and primary amines, respectively. It effectively prevents the longitudinal fusion of stabilized Microtubules (MTs), which retain a consistent mean length regardless of incubation duration. This has been demonstrated in experiments where MTs, upon treatment with 250 μM Sulfo-SMCC, were observed at intervals of 0 hours, 6 hours, and 24 hours, showing no change in length over time[1]. |
Molecular Weight | 436.37 |
Formula | C16H17N2NaO9S |
CAS No. | 92921-24-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 12 mg/mL (27.50 mM), Sonication is recommended.
DMSO: 125 mg/mL (286.45 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Sulfo-SMCC sodium 92921-24-9 Others Inhibitor Sulfo SMCC sodium SulfoSMCC sodium ADC Linkers Antibody-drug conjugates linkers inhibit Sulfo-SMCC inhibitor