store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sulamserod (RS 100302) is a potent 5-HT4 receptor antagonist with antiarrhythmic activity for the study of atrial fibrillation and cardiovascular related diseases.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 700.00 | |
5 mg | In stock | $ 1,800.00 |
Description | Sulamserod (RS 100302) is a potent 5-HT4 receptor antagonist with antiarrhythmic activity for the study of atrial fibrillation and cardiovascular related diseases. |
In vivo |
In pigs, the administration of Sulamserod at a dose of 30 mg/kg results in significant effects on electrophysiological parameters. Specifically, Sulamserod prolongs the mean effective refractory period (ERP) (14667 ms versus 11568 ms, P < 0.01) and wavelength (9.960.8 cm versus 8.360.9 cm, P < 0.01). Additionally, it reduces the dispersion of ERP (861 ms versus 1565 ms, P < 0.01) and causes a minimal slowing of conduction velocity (6765 cm/s versus 7264 cm/s, P < 0.01). Notably, Sulamserod does not induce any ventricular electrophysiological effects. Moreover, its administration leads to the termination of atrial flutter in 6 out of 8 animals and atrial fibrillation in 8 out of 9 animals. Furthermore, Sulamserod effectively prevents the reinduction of sustained tachycardia in all animals[1]. |
Synonyms | RS-100302 |
Molecular Weight | 445.96 |
Formula | C19H28ClN3O5S |
CAS No. | 219757-90-1 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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Sulamserod 219757-90-1 GPCR/G Protein Neuroscience 5-HT Receptor RS100302 RS 100302 RS-100302 inhibitor inhibit