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Sodium Picosulfate

Catalog No. T6675 CAS 10040-45-6

Synonyms: Evacuol, Picolax, Sodium Picosulphate, Laxoberal

Sodium Picosulfate (Laxoberal) inhibits absorption of water and electrolytes, and increases their secretion.

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Sodium Picosulfate, CAS 10040-45-6

Pack Size	Availability	Price/USD
10 mg	In stock	$ 40.00
50 mg	In stock	$ 68.00
100 mg	In stock	$ 120.00
200 mg	In stock	$ 158.00
500 mg	In stock	$ 263.00
1 mL * 10 mM (in DMSO)	In stock	$ 37.00

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Purity: 99.1%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Sodium Picosulfate (Laxoberal) inhibits absorption of water and electrolytes, and increases their secretion.
In vitro	Sodium Picosulfate displays cytotoxic effects on cultured liver cells. 800 and 1600 mg/mL induces dose-dependently vacuolic and fatty change as well as necrosis combined with a lowered mitotic activity and a slight increase in LDH values of the rapidly growing cultured liver cells of rabbit. Comparable but less severe effects are observed in 4-day old liver cell cultures of rat, while liver cells cultured for 6 to 11 days tolerate 1600 mg/mL Sodium Picosulfate. In human liver cultures the number of cells is slightly lowered at 800 and 1600 mg/mL and the number of nuclei in division is decreased dependent on dose. [1]
In vivo	Sodium Picosulphate treatment for long-term has no effects on neuropeptide content of the rat colon. Over a 6-month period, daily doses (10 mg/kg/day) or twice-weekly doses (7.5 mg/kg/day) of Sodium Picosulphate do not affect the level of Vasoactive intestinal polypeptide (VIP), somatostatin, and substance P in mucosa, submucosa, or muscularis externa. [2] Sodium Picosulphate has no major influence on ileal and colonic epithelial cell proliferation. In a 12 weeks study, 10 mg/kg Sodium Picosulphate continuously treatment does not influence the labeling index of Brdu (LI) in the ileum and induces no statistically significant increase of the LI when the treated groups are compared with the control group. The proliferative pattern along the crypts remains unchanged with sodium picosulphate treatment throughout the study. [3] Sodium Picosulphate does not induce chronic changes in colonic motility in rats under long-term treatment. 10 mg/kg/day Sodium Picosulphate pretreated for 23 weeks does not induce any significant change in the duration of long spike bursts (LSB) which are associated with phasic contractions, or in LSB frequency in the fasted state or after a 3-gram meal. [4]

Synonyms	Evacuol, Picolax, Sodium Picosulphate, Laxoberal
Molecular Weight	481.41
Formula	C18H15NO8S2·2Na
CAS No.	10040-45-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 3 mg/mL (6.23 mM)

H2O: 88 mg/mL (182.8 mM)

DMSO: 50 mg/mL (103.86 mM)

References and Literature

1. Nishikawa J, et al. Arzneimittelforschung, 1981, 31(2), 321-325. 2. Tzavella K, et al. Eur J Gastroenterol Hepatol, 1995, 7(1), 13-20. 3. Geboes K, et al. Pharmacology, 1993, 47 Suppl 1, 187-195. 4. Fioramonti J, et al. Pharmacology, 1993, 47 Suppl 1, 155-161.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Pediatric Drug Library Bioactive Compound Library Orally Active Compound Library FDA-Approved & Pharmacopeia Drug Library Anti-Metabolism Disease Compound Library NO PAINS Compound Library Bioactive Compounds Library Max Approved Drug Library FDA-Approved Drug Library

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Sodium Picosulfate 10040-45-6 Others inhibit Inhibitor Evacuol Picolax Sodium Picosulphate Laxoberal inhibitor

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