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Sodium Oxamate

Name: Sodium Oxamate
Brand: TargetMol
SKU: T19831
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19831Cas No. 565-73-1

Alias SO, Oxamic acid sodium salt, oxamate sodium, Aminooxoacetic acid sodium salt

Sodium Oxamate (Oxamic acid sodium salt) is an LDH inhibitor that specifically inhibits LDHA. Sodium Oxamate has antitumor activity and induces cell cycle arrest and apoptosis.

Sodium Oxamate

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Purity: 99.23%

Catalog No. T19831Alias SO, Oxamic acid sodium salt, oxamate sodium, Aminooxoacetic acid sodium saltCas No. 565-73-1

Sodium Oxamate (Oxamic acid sodium salt) is an LDH inhibitor that specifically inhibits LDHA. Sodium Oxamate has antitumor activity and induces cell cycle arrest and apoptosis.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$31	In Stock	In Stock
1 mL x 10 mM (in H2O)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.23%

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Sodium Oxamate (Oxamic acid sodium salt) is an LDH inhibitor that specifically inhibits LDHA. Sodium Oxamate has antitumor activity and induces cell cycle arrest and apoptosis.
Targets&IC50	A549 cells:19.67 ± 1.53 mM, H1299 cells:32.13 ± 2.50 mM, HBE:96.73 ± 7.60 mM, MIAPaCa2 cells:18.9 mM
In vitro	METHODS: Human lung cancer cells H1299, A549 and normal human bronchial epithelial cells HBE were treated with Sodium Oxamate (1-100 mmol/L) for 24 h. Cell viability was measured by CCK-8 assay. RESULTS: Sodium Oxamate significantly inhibited the cell viability of H1299 and A549 cells in a dose-dependent manner, with IC50 of 32.13±2.50 and 19.67±1.53 mmol/L, respectively. Sodium Oxamate had almost no effect on HBE cells, with an IC50 of 96.73±7.60 mmol/L. [1]. METHODS: Human lung cancer cells A549 and normal human bronchial epithelial cells HBE were treated with Sodium Oxamate (20-100 mmol/L) for 24 h, and several intracellular biochemical parameters were measured. RESULTS: LDH activity, ATP content and NADPH/NADP ratio were significantly decreased and ROS content was significantly increased in A549 cells after Sodium Oxamate treatment. In contrast, glucose metabolism was less affected, although LDH enzyme was also inhibited in a dose-dependent manner in HBE cells. [2]
In vivo	METHODS: To detect the antitumor activity in vivo, Sodium Oxamate (300 mg/kg once a day) and pembrolizumab (10 mg/kg twice a week) were intraperitoneally injected into B-NDG mice carrying human lung cancer tumor H1299 for fifteen days. RESULTS: Both Sodium Oxamate and pembrolizumab significantly delayed tumor growth in monotherapy, and the combination therapy was more effective. [1] METHODS: To explore the potential for the treatment of diabetes, Sodium Oxamate (350-750 mg/kg) was administered intraperitoneally to db/db mice once daily for twelve weeks. RESULTS: Sodium Oxamate treatment reduced body weight gain, blood glucose and HbA1c levels, and improved insulin secretion, pancreatic islet morphology, and insulin sensitivity in db/db mice.Sodium Oxamate improves glycemic control and insulin sensitivity in db/db mice, primarily by inhibiting the production of tissue lactic acid. [3]
Synonyms	SO, Oxamic acid sodium salt, oxamate sodium, Aminooxoacetic acid sodium salt

Chemical Properties

Molecular Weight	111.03
Formula	C₂H₂NNaO₃
Cas No.	565-73-1
Smiles	[Na+].NC(=O)C([O-])=O
Relative Density.	no data available

Storage & Solubility Information

Storage

store under nitrogen | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 25.5 mg/mL (229.67 mM), Sonication is recommended.

DMSO: Insoluble

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	9.0066 mL	45.0329 mL	90.0657 mL	450.3287 mL
5 mM	1.8013 mL	9.0066 mL	18.0131 mL	90.0657 mL
10 mM	0.9007 mL	4.5033 mL	9.0066 mL	45.0329 mL
20 mM	0.4503 mL	2.2516 mL	4.5033 mL	22.5164 mL
50 mM	0.1801 mL	0.9007 mL	1.8013 mL	9.0066 mL
100 mM	0.0901 mL	0.4503 mL	0.9007 mL	4.5033 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc