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Sodium Oxamate

Catalog No. T19831 CAS 565-73-1

Synonyms: oxamate sodium, Oxamic acid sodium salt, Aminooxoacetic acid sodium salt, SO

Sodium Oxamate (Oxamic acid sodium salt) is an LDH inhibitor that specifically inhibits LDHA. Sodium Oxamate has antitumor activity and induces cell cycle arrest and apoptosis.

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Sodium Oxamate, CAS 565-73-1

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1 g	In stock	$ 31.00
1 mL * 10 mM (in H2O)	In stock	$ 39.00

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Description	Sodium Oxamate (Oxamic acid sodium salt) is an LDH inhibitor that specifically inhibits LDHA. Sodium Oxamate has antitumor activity and induces cell cycle arrest and apoptosis.
In vitro	METHODS: Human lung cancer cells H1299, A549 and normal human bronchial epithelial cells HBE were treated with Sodium Oxamate (1-100 mmol/L) for 24 h. Cell viability was measured by CCK-8 assay. RESULTS: Sodium Oxamate significantly inhibited the cell viability of H1299 and A549 cells in a dose-dependent manner, with IC50 of 32.13±2.50 and 19.67±1.53 mmol/L, respectively. Sodium Oxamate had almost no effect on HBE cells, with an IC50 of 96.73±7.60 mmol/L. [1]. METHODS: Human lung cancer cells A549 and normal human bronchial epithelial cells HBE were treated with Sodium Oxamate (20-100 mmol/L) for 24 h, and several intracellular biochemical parameters were measured. RESULTS: LDH activity, ATP content and NADPH/NADP ratio were significantly decreased and ROS content was significantly increased in A549 cells after Sodium Oxamate treatment. In contrast, glucose metabolism was less affected, although LDH enzyme was also inhibited in a dose-dependent manner in HBE cells. [2]
In vivo	METHODS: To detect the antitumor activity in vivo, Sodium Oxamate (300 mg/kg once a day) and pembrolizumab (10 mg/kg twice a week) were intraperitoneally injected into B-NDG mice carrying human lung cancer tumor H1299 for fifteen days. RESULTS: Both Sodium Oxamate and pembrolizumab significantly delayed tumor growth in monotherapy, and the combination therapy was more effective. [1] METHODS: To explore the potential for the treatment of diabetes, Sodium Oxamate (350-750 mg/kg) was administered intraperitoneally to db/db mice once daily for twelve weeks. RESULTS: Sodium Oxamate treatment reduced body weight gain, blood glucose and HbA1c levels, and improved insulin secretion, pancreatic islet morphology, and insulin sensitivity in db/db mice.Sodium Oxamate improves glycemic control and insulin sensitivity in db/db mice, primarily by inhibiting the production of tissue lactic acid. [3]

Synonyms	oxamate sodium, Oxamic acid sodium salt, Aminooxoacetic acid sodium salt, SO
Molecular Weight	111.03
Formula	C2H2NNaO3
CAS No.	565-73-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 16.67mg/ml（150mM）, Sonication is recommended.

DMSO: Insoluble

References and Literature

1. Qiao T, et al. Inhibition of LDH-A by Oxamate Enhances the Efficacy of Anti-PD-1 Treatment in an NSCLC Humanized Mouse Model. Front Oncol. 2021 Mar 30;11:632364. 2. Yang Y, et al. Different effects of LDH-A inhibition by oxamate in non-small cell lung cancer cells. Oncotarget. 2014 Dec 15;5(23):11886-96. 3. Ye W, et al. Oxamate Improves Glycemic Control and Insulin Sensitivity via Inhibition of Tissue Lactate Production in db/db Mice. PLoS One. 2016 Mar 3;11(3):e0150303.

Citations

1. Su G, Liu J, Duan C, et al.Enteric coronavirus PDCoV evokes a non-Warburg effect by hijacking pyruvic acid as a metabolic hub.Redox Biology.2024: 103112.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Apoptosis Compound Library Anti-Breast Cancer Compound Library Mitochondria-Targeted Compound Library Anti-Pancreatic Cancer Compound Library Anti-Metabolism Disease Compound Library Metabolism Compound Library NO PAINS Compound Library Cell Cycle Compound Library Bioactive Compound Library

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Keywords

Sodium Oxamate 565-73-1 Apoptosis Cell Cycle/Checkpoint Metabolism Dehydrogenase CDK Aminooxoacetic acid sodium oxamate sodium Oxamic acid sodium salt Aminooxoacetic acid sodium salt SO Oxamic acid sodium inhibitor inhibit

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