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Sanggenol L

Catalog No. TN2177 CAS 329319-20-2

Sanggenol L shows higher cytotoxicity against human oral tumor cell lines (HSC-2 and HSG) than against normal human gingival fibroblasts (HGF), it induces Apoptosis via Caspase activation and inhibition of NF-Κb/IκBα± phosphorylation as a potent chemotherapeutic agent for ovarian cancers.

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Sanggenol L, CAS 329319-20-2

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Purity: 98%

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Description

Sanggenol L shows higher cytotoxicity against human oral tumor cell lines (HSC-2 and HSG) than against normal human gingival fibroblasts (HGF), it induces apoptosis via caspase activation and inhibition of NF-κB/IκBα± phosphorylation as a potent chemotherapeutic agent for ovarian cancers.

In vitro

Chemical structures were determined based on spectroscopic data analyses including NMR, MS, CD, and IR. For the first time, compounds 1 and 7 were isolated from the root bark of M. alba. All compounds were evaluated for hepatoprotective activity on t-BHP-induced oxidative stress in HepG2 cells and neuroprotective activity on glutamate-induced cell death in HT22 cells. Compounds 1, 4, 8, 10, and 11 showed protective effects on t-BHP-induced oxidative stress with EC50 values of 6.94 ± 0.38, 30.32 ± 6.82, 23.45 ± 4.72, 15.31 ± 2.21, and 0.41 ± 0.48 μM, respectively, and compounds 1, 2, 10, 11, and 12 showed protective effects on glutamate-induced cell death with EC50 values of 5.54 ± 0.86, 34.03 ± 7.71, 19.71 ± 0.71, 16.50 ± 7.82, and 1.02 ± 0.13 μM, respectively[1]

Molecular Weight	422.47
Formula	C25H26O6
CAS No.	329319-20-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Isoprenylated flavonoids from the root bark of Morus alba and their hepatoprotective and neuroprotective activities.Arch Pharm Res. 2015 Nov;38(11):2066-75.

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Keywords

Sanggenol L 329319-20-2 Cell Cycle/Checkpoint NF-Κb c-Myc NF-κB Inhibitor inhibitor inhibit

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