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SDZ281-977

Catalog No. T16866 CAS 150779-71-8

Synonyms: SDZ-LAP 977

SDZ 281-977 is a derivative of Lavendustin A which is the EGF receptor tyrosine kinase inhibitor.

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SDZ281-977, CAS 150779-71-8

Pack Size	Availability	Price/USD
25 mg	In stock	$ 954.00
50 mg	In stock	$ 1,240.00
100 mg	In stock	$ 1,990.00

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Biological Description

Chemical Properties

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Description	SDZ 281-977 is a derivative of Lavendustin A which is the EGF receptor tyrosine kinase inhibitor.
In vitro	The anticancer profile of SDZ 281-977 is investigated in nude mice bearing the human tumor cell lines A431 (vulvar carcinoma cells), MIA PaCa-2 (pancreatic tumor cells), and MDA-MB-231 (breast carcinoma cells). For inhibition of growth of A431, MIA PaCa-2, and MDA-MB-231 cells the IC50 values are 0.21 μM, 0.29 μM, and 0.43 μM, respectively [1].
In vivo	Nude mice bearing A431 human vulvar carcinomas receive intravenous injections of SDZ 281-977 (1-10 mg/kg) for 4 weeks. This treatment results in a dose-dependent inhibition of tumor growth. SDZ 281-977 (30 mg/kg, p.o.) treatment causes a 54% inhibition of A431 tumor growth after 3 weeks of treatment [1].

Synonyms	SDZ-LAP 977
Molecular Weight	316.35
Formula	C18H20O5
CAS No.	150779-71-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Cammisuli S, et al. SDZ 281-977: a modified partial structure of lavendustin A that exerts potent and selective antiproliferative activities in vitro and in vivo. Int J Cancer. 1996 Jan 26;65(3):351-9.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SDZ281-977 150779-71-8 Others SDZ281 977 SDZ-281-977 SDZ281977 SDZ-LAP 977 SDZ-LAP-977 SDZ-LAP977 inhibitor inhibit

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