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SDZ281-977

Name: SDZ281-977
Brand: TargetMol
SKU: T16866
Price: 100 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16866Cas No. 150779-71-8

Alias SDZ-LAP 977

SDZ 281-977 is a derivative of Lavendustin A, an EGF receptor tyrosine kinase inhibitor.

SDZ281-977

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Purity: 99.64%

Catalog No. T16866Alias SDZ-LAP 977Cas No. 150779-71-8

SDZ 281-977 is a derivative of Lavendustin A, an EGF receptor tyrosine kinase inhibitor.

Pack Size	Price	Availability
1 mg	$100	In Stock
5 mg	$247	In Stock
10 mg	$396	In Stock
25 mg	$793	In Stock
50 mg	$1,230	In Stock
1 mL x 10 mM (in DMSO)	$272	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.64%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	SDZ 281-977 is a derivative of Lavendustin A, an EGF receptor tyrosine kinase inhibitor.
In vitro	The anticancer activity of SDZ 281-977 is evaluated in nude mice with human tumor cell lines A431 (vulvar carcinoma cells), MIA PaCa-2 (pancreatic tumor cells), and MDA-MB-231 (breast carcinoma cells). The IC50 values for growth inhibition of A431, MIA PaCa-2, and MDA-MB-231 cells are 0.21 μM, 0.29 μM, and 0.43 μM, respectively [1].
In vivo	Intravenous administration of SDZ 281-977 (1-10 mg/kg) for 4 weeks in nude mice with A431 human vulvar carcinomas results in dose-dependent tumor growth inhibition. Additionally, oral administration of SDZ 281-977 (30 mg/kg) leads to a 54% inhibition of A431 tumor growth after 3 weeks of treatment [1].
Synonyms	SDZ-LAP 977

Chemical Properties

Molecular Weight	316.35
Formula	C₁₈H₂₀O₅
Cas No.	150779-71-8
Smiles	COC(=O)c1cc(CCc2cc(OC)ccc2OC)ccc1O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (252.88 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1611 mL	15.8053 mL	31.6106 mL	158.0528 mL
5 mM	0.6322 mL	3.1611 mL	6.3221 mL	31.6106 mL
10 mM	0.3161 mL	1.5805 mL	3.1611 mL	15.8053 mL
20 mM	0.1581 mL	0.7903 mL	1.5805 mL	7.9026 mL
50 mM	0.0632 mL	0.3161 mL	0.6322 mL	3.1611 mL
100 mM	0.0316 mL	0.1581 mL	0.3161 mL	1.5805 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc