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SDZ281-977

Name: SDZ281-977
Brand: TargetMol
SKU: T16866
Price: 100 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16866Cas No. 150779-71-8

Alias SDZ-LAP 977

SDZ 281-977 is a derivative of Lavendustin A, an EGF receptor tyrosine kinase inhibitor.

SDZ281-977

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Purity: 99.64%

Catalog No. T16866Alias SDZ-LAP 977Cas No. 150779-71-8

SDZ 281-977 is a derivative of Lavendustin A, an EGF receptor tyrosine kinase inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$100	-	In Stock
5 mg	$247	In Stock	In Stock
10 mg	$396	-	In Stock
25 mg	$793	-	In Stock
50 mg	$1,230	-	In Stock
1 mL x 10 mM (in DMSO)	$272	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.64%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	SDZ 281-977 is a derivative of Lavendustin A, an EGF receptor tyrosine kinase inhibitor.
In vitro	The anticancer activity of SDZ 281-977 is evaluated in nude mice with human tumor cell lines A431 (vulvar carcinoma cells), MIA PaCa-2 (pancreatic tumor cells), and MDA-MB-231 (breast carcinoma cells). The IC50 values for growth inhibition of A431, MIA PaCa-2, and MDA-MB-231 cells are 0.21 μM, 0.29 μM, and 0.43 μM, respectively [1].
In vivo	Intravenous administration of SDZ 281-977 (1-10 mg/kg) for 4 weeks in nude mice with A431 human vulvar carcinomas results in dose-dependent tumor growth inhibition. Additionally, oral administration of SDZ 281-977 (30 mg/kg) leads to a 54% inhibition of A431 tumor growth after 3 weeks of treatment [1].
Synonyms	SDZ-LAP 977

Chemical Properties

Molecular Weight	316.35
Formula	C₁₈H₂₀O₅
Cas No.	150779-71-8
Smiles	COC(=O)c1cc(CCc2cc(OC)ccc2OC)ccc1O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (252.88 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1611 mL	15.8053 mL	31.6106 mL	158.0528 mL
5 mM	0.6322 mL	3.1611 mL	6.3221 mL	31.6106 mL
10 mM	0.3161 mL	1.5805 mL	3.1611 mL	15.8053 mL
20 mM	0.1581 mL	0.7903 mL	1.5805 mL	7.9026 mL
50 mM	0.0632 mL	0.3161 mL	0.6322 mL	3.1611 mL
100 mM	0.0316 mL	0.1581 mL	0.3161 mL	1.5805 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc