Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SAR7334 (TRCP6-IN-1) is a potent and specific inhibitor of TRPC6(IC50 of 7.9 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 65.00 | |
5 mg | In stock | $ 163.00 | |
10 mg | In stock | $ 263.00 | |
25 mg | In stock | $ 425.00 | |
50 mg | In stock | $ 597.00 | |
100 mg | In stock | $ 747.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 178.00 |
Description | SAR7334 (TRCP6-IN-1) is a potent and specific inhibitor of TRPC6(IC50 of 7.9 nM). |
Targets&IC50 | TRPC6:7.9 nM |
In vitro | SAR7334 is an inhibitor of TRPC6, TRPC3 and TRPC7-mediated Ca2+ influx into cells(IC50s of 9.5, 282 and 226 nM)[1][2][3], whereas TRPC4 and TRPC5-mediated Ca2+ entry is not affected. SAR7334 (1 μM) results in a major block of the Ang II-evoked calcium influx in the podocytes[1].SAR7334 dose-dependently reduces TRPC6 currents (IC50 of 7.9 nM). SAR7334 (100 nM) substantially reduces TRPC6 currents[3]. |
In vivo | In isolated perfused lungs from mice, SAR7334 (10mg/kg, p.o.) inhibits TRPC6-dependent acute HPV . SAR7334 demonstrates that it is suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR)[3]. |
Synonyms | TRCP6-IN-1 |
Molecular Weight | 367.87 |
Formula | C21H22ClN3O |
CAS No. | 1333210-07-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 350 mg/mL (951.42 mM)
You can also refer to dose conversion for different animals. More
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SAR7334 1333210-07-3 Membrane transporter/Ion channel TRP/TRPV Channel TRP Channel SAR-7334 TRCP6-IN-1 SAR 7334 Inhibitor inhibit Transient receptor potential channels inhibitor