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Roluperidone

Catalog No. T15034 CAS 359625-79-9

Synonyms: CYR-101, MIN-101, MT-210

Roluperidone (CYR-101) is a novel cyclic amide derivative. It has high equipotent affinities for 5-HT2A and σ2 receptors (Ki of 7.53 nM and 8.19 nM for 5-HT2A and σ2).

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Roluperidone, CAS 359625-79-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 44.00
5 mg	In stock	$ 97.00
10 mg	In stock	$ 155.00
25 mg	In stock	$ 278.00
50 mg	In stock	$ 455.00
100 mg	In stock	$ 672.00
1 mL * 10 mM (in DMSO)	In stock	$ 98.00

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Purity: 97.77%

Purity: 96.46%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Roluperidone (CYR-101) is a novel cyclic amide derivative. It has high equipotent affinities for 5-HT2A and σ2 receptors (Ki of 7.53 nM and 8.19 nM for 5-HT2A and σ2).
Targets&IC50	σ2:8.19 nM(ki), 5-HT2A:7.53 nM(ki)
In vitro	Roluperidone shows binding affinity for α1-adrenergic receptors. Which low or no affinity for muscarinic, cholinergic, and histaminergic receptors. Although Roluperidone (CYR-101) has no affinities for pre- or postsynaptic dopaminergic receptors, it is probable that sigma-2 receptors are implicated in the modulation of dopamine and glutamatergic pathways and in calcium neuronal modulation[1].

Synonyms	CYR-101, MIN-101, MT-210
Molecular Weight	366.43
Formula	C22H23FN2O2
CAS No.	359625-79-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 0.1 mg/mL (insoluble)

DMSO: 33.33 mg/mL (90.96 mM), Sonification is recommended.

References and Literature

1. Davidson M, et al. Efficacy and Safety of MIN-101: A 12-Week Randomized, Double-Blind, Placebo-Controlled Trial of a New Drug in Development for the Treatment of Negative Symptoms in Schizophrenia. Am J Psychiatry. 2017 Jul 28:appiajp201717010122.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Drug Repurposing Compound Library Anti-Neurodegenerative Disease Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Serotonin Receptor-Targeted Compound Library Bioactive Compound Library Clinical Compound Library NO PAINS Compound Library Anti-Cancer Compound Library

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Related compounds with same targets

S1R agonist 1 hydrochloride BMY-14802 hydrochloride AB21 oxalate BD1063 dhydrochloride Sigma-1 receptor antagonist 2 PD 144418 Blonanserin AB21 HCl

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Roluperidone 359625-79-9 GPCR/G Protein Neuroscience Sigma receptor 5-HT Receptor MIN101 CYR-101 5-hydroxytryptamine Receptor MT 210 Inhibitor MIN-101 MT-210 CYR 101 inhibit MT210 MIN 101 Sigma Receptor CYR101 Serotonin Receptor inhibitor

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