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Endocrinology/Hormones Thyroid hormone receptor(THR) REVERSE T3

REVERSE T3

Catalog No. T7578   CAS 5817-39-0
Synonyms: reverse T3, 3,3',5'-triiodo-L-thyronine,

reverse T3 inhibits the increase of sodium current generated by other thyroid hormone analogs in neonatal rat myocytes.

REVERSE T3, CAS 5817-39-0
Pack Size Availability Price/USD Quantity
2 mg In stock 65.00
5 mg In stock 93.00
10 mg In stock 174.00
25 mg In stock 344.00
50 mg In stock 517.00
100 mg In stock 775.00
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Biological Description
Chemical Properties
Storage & Solubility Information
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Description reverse T3 inhibits the increase of sodium current generated by other thyroid hormone analogs in neonatal rat myocytes.
Targets&IC50 Thyroid hormone,  
In vitro Reverse T3(T3) pre-conditioning leads to beneficial effects in the liver of brain-dead rats as seen by lower cellular injury and reduced apoptosis, and supports the suggested role of reverse T3(T3) hormone therapy in the management of brain-dead donors[1].
Cell Research
Brain death (BD) was induced in mechanically ventilated rats by inflation of a Fogarty catheter in the epidural space. T3 (0.1 mg/kg) or vehicle was administered intraperitoneally 2 h prior to BD induction. After 4 h of BD, serum and liver tissue were collected. RT-qPCR, routine biochemistry, and immunohistochemistry were performed[1].
Synonyms reverse T3 , 3,3',5'-triiodo-L-thyronine ,
Purity 97.66%
Molecular Weight 650.97
Formula C15H12I3NO4
CAS No. 5817-39-0

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 32.55mg/mL(50mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Solution 1

Citations

References and Literature
1. Rebolledo R A , Erp A C V , Ottens P J , et al. Anti-Apoptotic Effects of 3,3’,5-Triiodo-L-Thyronine in the Liver of Brain-Dead Rats[J]. PLOS ONE, 2015, 10(4):249-250. 2. Nicod P , Burger A , Staeheli V , et al. Radioimmunoassay for 3,3',5'-triiodo-L-thyronine in unextracted serum: method and clinical results[J]. J Clin Endocrinol Metab, 1976, 42(5):823-829.

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Taltirelin acetate KAT681 L-Thyroxine sodium salt pentahydrate CO23 Levothyroxine sodium MGL3196 Liothyronine sodium O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine

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