Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PFE-360 (PF-06685360) is a potent and selective inhibitor of LRRK2 kinase (IC50: 2.3 nM in vivo).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 68.00 | |
2 mg | In stock | $ 98.00 | |
5 mg | In stock | $ 172.00 | |
10 mg | In stock | $ 239.00 | |
25 mg | In stock | $ 488.00 | |
50 mg | In stock | $ 716.00 | |
100 mg | In stock | $ 987.00 | |
500 mg | In stock | $ 1,980.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 189.00 |
Description | PFE-360 (PF-06685360) is a potent and selective inhibitor of LRRK2 kinase (IC50: 2.3 nM in vivo). |
Targets&IC50 | LRRK2:2.3 nM (IC50) |
In vivo | PFE-360 (4 mg/kg and 7.5 mg/kg, orally, BID, 10-12 weeks) treatment effectively reduces the LRRK2-pSer935/total LRRK2 ratio. It has no significant adverse effects[1]. |
Synonyms | PF-06685360 |
Molecular Weight | 308.34 |
Formula | C16H16N6O |
CAS No. | 1527475-61-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10.2 mg/mL (33.08 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
PFE-360 1527475-61-1 Autophagy LRRK2 PF 06685360 PFE 360 inhibit PFE360 Inhibitor Leucine-rich repeat kinase 2 PF-06685360 PF06685360 inhibitor