Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PF429242 dihydrochloride can reversibly inhibit S1P (IC50 of 175 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 36.00 | |
2 mg | In stock | $ 52.00 | |
5 mg | In stock | $ 85.00 | |
10 mg | In stock | $ 148.00 | |
25 mg | In stock | $ 297.00 | |
50 mg | In stock | $ 545.00 | |
100 mg | In stock | $ 785.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 94.00 |
Description | PF429242 dihydrochloride can reversibly inhibit S1P (IC50 of 175 nM). |
Targets&IC50 | S1P:175 nM |
In vitro | 10 μM PF-429242 down-regulates the signal from an SRE-luciferase reporter gene in human embryonic kidney 293 cells and the expression of endogenous SREBP target genes in cultured HepG2 cells. In HepG2 cells, PF-429242 inhibits cholesterol synthesis, with an IC50 of 0.5 μM[1]. PF-429242 treatment also shows suppressive effects on DENV2 yields in the cultured fluids of human-derived HEK-293, Hep G2, and non-human-primate derived LLC-MK2 cells[2]. PF-429242 has potent antiviral against LCMV and LASV [3]. |
In vivo | PF-429242 inhibits the expression of hepatic SREBP target genes, and the hepatic rates of cholesterol and fatty acid synthesis are reduced In mice[1]. |
Molecular Weight | 482.49 |
Formula | C25H37Cl2N3O2 |
CAS No. | 2248666-66-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 50 mg/mL (103.63 mM), Sonification is recommended.
DMSO: 83.3 mg/mL (165.81 mM)
You can also refer to dose conversion for different animals. More
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PF429242 dihydrochloride 2248666-66-0 GPCR/G Protein S1P Receptor PF429242 PF-429242 Dihydrochloride PF-429242 dihydrochloride Virus Protease inhibit Inhibitor PF 429242 Dihydrochloride PF-429242 Fatty Acid Synthase (FASN) PF 429242 PF429242 Dihydrochloride inhibitor