Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PF 06446846 is a potent and selective PCSK9 inhibitor
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 93.00 | |
2 mg | In stock | $ 133.00 | |
5 mg | In stock | $ 196.00 | |
10 mg | In stock | $ 295.00 | |
25 mg | In stock | $ 543.00 | |
50 mg | In stock | $ 783.00 | |
100 mg | In stock | $ 1,090.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 243.00 |
Description | PF 06446846 is a potent and selective PCSK9 inhibitor |
In vivo | PF-06446846 reduces plasma PCSK9 and total cholesterol levels in rats following oral dosing.?PF-06446846 is highly selective for the inhibition of PCSK9 translation.?The mechanism of action employed by PF-06446846 reveals a previously unexpected tunability of the human ribosome that allows small molecules to specifically block translation of individual transcripts. |
Molecular Weight | 433.89 |
Formula | C22H20ClN7O |
CAS No. | 1632250-49-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.34 mg/mL (10 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
PF-06446846 1632250-49-7 Others Threonine proteases PF 06446846 Inhibitor 80S ribosome Selective Ser/Thr Protease Serine proteases Rat bone marrow Huh7 inhibit PF06446846 Serine endopeptidases inhibitor