Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PD180970 is an inhibitor of Bcr-Abl with IC50s of 5 nM, 0.8 nM and 50 nM for the autophosphorylation of p210Bcr-Abl, Src and Kit. PD180970 can be used in studies about chronic myelogenous leukemia.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 34.00 | |
5 mg | In stock | $ 89.00 | |
10 mg | In stock | $ 147.00 | |
25 mg | In stock | $ 246.00 | |
50 mg | In stock | $ 369.00 | |
100 mg | In stock | $ 543.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 97.00 |
Description | PD180970 is an inhibitor of Bcr-Abl with IC50s of 5 nM, 0.8 nM and 50 nM for the autophosphorylation of p210Bcr-Abl, Src and Kit. PD180970 can be used in studies about chronic myelogenous leukemia. |
Targets&IC50 | c-Kit:50 nM, Src:0.8 nM, BCR-ABL:5 nM (Ip210Bcr-Ablkinase) |
In vitro | In K562 cells, PD180970 (0.5 μM) induces apoptosis and causes cell death. The IC50 values are 170, 80, and 80 nM for the tyrosine phosphorylation of p210Bcr-Abl, Gab2, and CrkL. PD180970 significantly inhibits the purified recombinant Abl tyrosine kinase activity with an IC50 of 2.2 nM[1]. In the human K562 CML cells, PD180970 inhibits the activity of Stat5 DNA-binding with an IC50 of 5 nM[2]. |
In vivo | In Male C57BL/6J mice injected with MPTP, intraperitonial injection of PD180970 (5 mg/kg) decreased number of activated microglia on activation by MPTP and reduces the Iba1 expression intensity in activated microglia[1]. |
Synonyms | PD 180970 |
Molecular Weight | 429.27 |
Formula | C21H15Cl2FN4O |
CAS No. | 287204-45-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90.0 mg/mL (209.7 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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PD180970 287204-45-9 Angiogenesis Cytoskeletal Signaling Tyrosine Kinase/Adaptors Bcr-Abl Src c-Kit PD-180970 PD 180970 inhibitor inhibit