Home Tools

Ostarine

Catalog No. T2408 CAS 841205-47-8

Synonyms: MK-2866, GTX-024, Enobosarm

Ostarine (MK-2866) is a non-steroidal agent with anabolic activity. Selective androgen receptor modulator (SARM) GTx-024 is designed to work like testosterone, thus promoting and/or maintaining libido, fertility, prostate growth, and muscle growth and strength. Mimicking testosterone's action, this agent may increase lean body mass, thereby ameliorating muscle wasting in the hypermetabolic state of cancer cachexia.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Ostarine, CAS 841205-47-8

Pack Size	Availability	Price/USD
25 mg	In stock	$ 36.00
50 mg	In stock	$ 72.00
100 mg	In stock	$ 122.00
500 mg	In stock	$ 295.00
1 mL * 10 mM (in DMSO)	In stock	$ 30.00

Bulk Inquiry

Select Batch

Purity: 99.9%

Purity: 99.35%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Ostarine (MK-2866) is a non-steroidal agent with anabolic activity. Selective androgen receptor modulator (SARM) GTx-024 is designed to work like testosterone, thus promoting and/or maintaining libido, fertility, prostate growth, and muscle growth and strength. Mimicking testosterone's action, this agent may increase lean body mass, thereby ameliorating muscle wasting in the hypermetabolic state of cancer cachexia.
Targets&IC50	Androgen receptor:3.8 nM(Ki)
In vitro	Compared to any non-steroidal androgen receptor (AR) agonists, Ostarine exhibits the highest androgenic and anabolic activity in the body, particularly affecting the prostate, seminal vesicles, and levator ani muscle, with ED50 values of 0.12, 0.39, and 0.03 mg/day, respectively. This makes it four times more effective on the levator ani muscle than testosterone propionate. At a low dose of 0.03 mg/day, Ostarine demonstrates effective and selective activity in anabolic tissues. Following a single intravenous injection of 10 mg/kg, Ostarine presents a slow decline in plasma concentration with a longer half-life of 6 hours, compared to the 2.6-4.0 hours half-life when targeting other cyan/nitro substituted Selective Androgen Receptor Modulators (SARMs). In castrated male rats, Ostarine shows significant androgenic and anabolic activity, more effectively stimulating growth in the prostate, seminal vesicles, and levator ani muscle than other cyan/nitro substituted SARMs. Ostarine facilitated recovery of prostate weight by 39.2%, seminal vesicle weight by 78.8%, and notably stimulated levator ani muscle growth beyond other male organs to 141.9%.
In vivo	Ostarine (10 nM) modulates the transcriptional activity of the androgen receptor (AR) in CV-1 cells co-transfected with human androgen receptor expression vectors, luciferase reporter vectors, and β-galactosidase control vectors. Ostarine binds to the androgen receptor with the highest affinity among selective androgen receptor modulators (SARMs), exhibiting a Ki value of 3.8 nM.

Synonyms	MK-2866, GTX-024, Enobosarm
Molecular Weight	389.33
Formula	C19H14F3N3O3
CAS No.	841205-47-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 72 mg/mL (184.9 mM)

DMSO: 72 mg/mL (184.9 mM)

References and Literature

1. Kim J, et al. J Pharmacol Exp Ther, 2005, 315(1), 230-239. 2. Duke CB, et al. J Med Chem, 2011, 54(11), 3973-3976.

Related compound libraries

This product is contained In the following compound libraries：

Fluorochemical Library

Related Products

Related compounds with same targets

2-hydroxy Flutamide VPC-14228 Apalutamide JNJ-63576253 free base Bavdegalutamide Testosterone undecanoate ORM-15341 Topterone

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below

Dosage

mg/kg

Average weight of animals

Dosing volume per animal

Number of animals

Step Two: Enter the in vivo formulation

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

Calculate Reset

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Calculator

Molarity Calculator

Dilution Calculator

Reconstitution Calculation

Molecular Weight Calculator

Mass

Concentration

Volume

Molecular Weight

Molarity Calculator allows you to calculate the

Mass of a compound required to prepare a solution of known volume and concentration
Volume of solution required to dissolve a compound of known mass to a desired concentration
Concentration of a solution resulting from a known mass of compound in a specific volume

See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

Concentration (Start)

Volume (Start)

Concentration (End)

Volume (End)

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Molecule Formula

Molecular Weight g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ostarine 841205-47-8 Endocrinology/Hormones Androgen Receptor MK2866 MK-2866 GTX-024 GTX 024 Enobosarm GTX024 MK 2866 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.