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OTSSP167 hydrochloride

Catalog No. T21559 CAS 1431698-10-0

OTSSP167 hydrochloride is a highly potent inhibitor of MELK(IC50 : 0.41 nM).

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OTSSP167 hydrochloride Chemical Structure

OTSSP167 hydrochloride, CAS 1431698-10-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 34.00
2 mg	In stock	$ 48.00
5 mg	In stock	$ 80.00
10 mg	In stock	$ 122.00
25 mg	In stock	$ 198.00
50 mg	In stock	$ 372.00
100 mg	In stock	$ 556.00
1 mL * 10 mM (in DMSO)	In stock	$ 93.00

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Purity: 99.97%

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Description	OTSSP167 hydrochloride is a highly potent inhibitor of MELK(IC50 : 0.41 nM).
Targets&IC50	MELK:0.41 nM (IC50)
In vitro	OTSSP167 is a highly potent MELK inhibitor with IC of 0.41 nM.?OTSSP167 inhibited the phosphorylation of PSMA1 (proteasome subunit alpha type 1) and DBNL (drebrin-like), which we identified as novel MELK substrates and are important for stem-cell characteristics and invasiveness.?The compound suppressed mammosphere formation of breast cancer cells and exhibited significant tumor growth suppression in xenograft studies using breast, lung, prostate, and pancreas cancer cell lines in mice by both intravenous and oral administration.?This MELK inhibitor should be a promising compound possibly to suppress the growth of tumor-initiating cells and be applied for treatment of a wide range of human cancer.

Molecular Weight	523.88
Formula	C25H29Cl3N4O2
CAS No.	1431698-10-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 33 mg/mL (63 mM), Sonication is recommended.

H2O: 7.14 mg/mL (13.63 mM), Sonication is recommended.

References and Literature

1. Chung S, Suzuki H, Miyamoto T, et al. Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer. Oncotarget. 2012 Dec 21. 2. Jurmeister S, et al. Identification of potential therapeutic targets in prostate cancer through a cross-species approach. EMBO Mol Med. 2018 Feb 5. pii: e8274.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Inhibitor Library Anti-Obesity Compound Library Glycolysis Compound Library Anti-Ovarian Cancer Compound Library Anti-Colorectal Cancer Compound Library PI3K-AKT-mTOR Compound Library Antidepressant Compound Library Neuronal Differentiation Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets

HTH-01-091 OTSSP167 MELK-IN-1 NMS-P715 MELK-8a hydrochloride MELK-8a Dihydrochloride JTV-519 hemifumarate Antitumor agent-116

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

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