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OG-L002

Catalog No. T6073 CAS 1357302-64-7

OG-L002 is an effective and selective LSD1 inhibitor (IC50: 20 nM), showing 69- and 36-fold selectivity over MAO-A and MAO-B, respectively.

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OG-L002, CAS 1357302-64-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 43.00
2 mg	In stock	$ 61.00
5 mg	In stock	$ 97.00
10 mg	In stock	$ 176.00
25 mg	In stock	$ 319.00
50 mg	In stock	$ 533.00
100 mg	In stock	$ 762.00
500 mg	In stock	$ 1,530.00
1 mL * 10 mM (in DMSO)	In stock	$ 48.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	OG-L002 is an effective and selective LSD1 inhibitor (IC50: 20 nM), showing 69- and 36-fold selectivity over MAO-A and MAO-B, respectively.
Targets&IC50	LSD1:20 nM
In vitro	OG-L002 potently inhibits HSV IE gene expression in both HeLa and HFF cells with IC50 of ~10 μM and ~3 μM , respectively. OG-L002 treatment (50 μM ) results in the reduced production of progeny virus with no significant toxicity in HeLa or HFF cells. OG-L002 (50 μM ) increases the levels of repressive chromatin on viral IE gene promoters. In addition, OG-L002 also represses the expression of hCMV IE genes and adenovirus E1A gene. [1]
In vivo	OG-L002 (6 to 40 mg/kg) represses HSV primary infection in a dose-dependent manner in a mouse model. Moreover, OG-L002 also represses HSV reactivation from latency in a mouse ganglion explant model. [1]
Kinase Assay	LSD1 demethylation assay: Human recombinant LSD1 protein is incubated with dimethylated H3K4 peptide as the substrate in the presence of various concentrations of lead compound inhibitors (0 to 75 μM ) or control tranylcypromine. The demethylase activity is measured by the release of Water2 produced during the catalytic process, using the Amplex red peroxide/peroxidase-coupled assay kit. Each reaction is done in triplicate. The maximum LSD1 demethylase activity is obtained in the absence of inhibitor and corrected for background fluorescence. The Ki (IC50) of OG-L002 is calculated as half-maximal activity.
Cell Research	HeLa or HFF cells are treated with the indicated concentrations of saponin (positive control) or compound OG-L002 for 12 hours. Cytotoxicity is determined using conditions recommended by the manufacturer and expressed as ratios to the cytotoxicity of the DMSO control.(Only for Reference)

Molecular Weight	225.29
Formula	C15H15NO
CAS No.	1357302-64-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 16 mg/mL (71 mM)

DMSO: 42 mg/mL (186.4 mM)

References and Literature

1. MBio. 2013, 4(1), e00558-12.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Neuronal Signaling Compound Library Anti-Infection Compound Library Bioactive Compounds Library Max Reprogramming Compound Library Histone Modification Compound Library Epigenetics Compound Library Anti-Viral Compound Library NO PAINS Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets

GSK J5 DDP-38003 dihydrochloride GSK-J4 KF21213 GSK2879552 LSD1-IN-27 Tranylcypromine (2-PCPA) hydrochloride PBIT

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

OG-L002 1357302-64-7 Chromatin/Epigenetic Microbiology/Virology Neuroscience Histone Demethylase HSV Monoamine Oxidase Inhibitor MAO-B LSD1 oxidases MAO inhibit monoamine Herpes simplex virus OGL002 MAO-A OG L002 OG-L-002 OG-L 002 inhibitor

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