Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Nosiheptide (Multhiomycin), a thiopeptide antibiotic synthesized by Streptomyces actuosus, serves as a potent feed additive to promote animal growth. It functions by hindering bacterial protein synthesis and is distinguished by an indole side ring system and regiospecific hydroxyl groups on its macrocyclic core.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 61.00 | |
5 mg | In stock | $ 140.00 | |
10 mg | In stock | $ 240.00 | |
25 mg | In stock | $ 420.00 | |
50 mg | In stock | $ 623.00 | |
100 mg | In stock | $ 887.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 322.00 |
Description | Nosiheptide (Multhiomycin), a thiopeptide antibiotic synthesized by Streptomyces actuosus, serves as a potent feed additive to promote animal growth. It functions by hindering bacterial protein synthesis and is distinguished by an indole side ring system and regiospecific hydroxyl groups on its macrocyclic core. |
In vitro | Nosiheptide demonstrates non-toxic behavior towards mammalian cells at concentrations greater than 100 times the minimum inhibitory concentration (MIC) and retains its effectiveness against Staphylococcus aureus in the presence of 20% human serum. It is particularly potent against Enterococcus spp., the hypervirulent BI strain of Clostridium difficile, and displays remarkable activity against all tested strains of Staphylococcus aureus, including those resistant to multiple drugs (MIC values ≤ 0.25 mg/L). Additionally, Nosiheptide exhibits a significantly extended post-antibiotic effect against both healthcare- and community-associated Staphylococcus aureus when compared to vancomycin. Through time-kill studies, Nosiheptide has been found to quickly eliminate Staphylococcus aureus in a concentration- and time-dependent manner, achieving a near 2-log reduction at 6 hours with a concentration 10 times the MIC [1]. |
In vivo | Nosiheptide (20 mg/kg; intraperitoneal injection; injected at 1 and 8 h post-infection; female CD1 mice) offers obviously protection against mortality. Ten out of 10 of the Nosiheptide-treated mice remain alive on day 3, while 6/10 of the controls died on day 1[1]. |
Synonyms | RP 9671, Multhiomycin |
Molecular Weight | 1222.36 |
Formula | C51H43N13O12S6 |
CAS No. | 56377-79-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (102.26 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Nosiheptide 56377-79-8 Microbiology/Virology Antibiotic Antibacterial RP9671 inhibit RP 9671 RP-9671 Multhiomycin Bacterial Inhibitor inhibitor