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Nigericin sodium salt

Catalog No. T3092 CAS 28643-80-3

Synonyms: 尼日利亚菌素钠盐, 尼日利亚菌素

Nigericin sodium salt is an antibiotic from Streptomyces hygroscopicus and is a NLRP3 activator.Nigericin sodium is a cationic ionophore that inhibits Golgi function and suppresses growth of gram positive bacteria. It also prevents viral activation and triggers activation of the NALP3 inflammasome.

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Nigericin sodium salt, CAS 28643-80-3

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vivo

A 48-hr exposure of human erythrocytes to nigericin significantly increased the percentage of annexin-V-binding cells (0.1-10 nM), significantly decreased forward scatter (0.1-1 nM), significantly decreased cytosolic pH (0.1-1 nM) and significantly increased Fluo3 fluorescence (0.1-10 nM).?Nigericin (1 nM) slightly, but significantly, increased ROS, but did not significantly modify ceramide abundance.?The effect of nigericin on annexin V binding was significantly blunted, but not abolished by removal of extracellular Ca(2+).?The nigericin-induced increase in [Ca(2+)]i and annexin V binding was again significantly blunted but not abolished by the Na(+)/H(+) exchanger inhibitor cariporide (10 μM).?Nigericin triggers eryptosis, an effect paralleled by ROS formation, in part dependent on stimulation of Ca(2+) entry, and involving the cariporide-sensitive Na(+)/H(+) exchanger[1].

Synonyms	尼日利亚菌素钠盐, 尼日利亚菌素
Molecular Weight	746.94
Formula	C40H67NaO11
CAS No.	28643-80-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

Methanol: 122 mg/mL (163.33mM)

Ethanol: 47 mg/mL (62.92mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Lim J, et al. J Biol Chem. 2012 Jul 6;287(28):23271-82. 1. Bissinger R, et al. Triggering of Suicidal Erythrocyte Death by the Antibiotic Ionophore Nigericin. Basic Clin Pharmacol Toxicol. 2016 May;118(5):381-9 2. Yakisich JS, et al. Nigericin decreases the viability of multidrug-resistant cancer cells and lung tumorspheres and potentiates the effects of cardiac glycosides. Tumour Biol. 2017 Mar;39(3):1010428317694310 3. Zhou HM, et al. Suppression of colorectal cancer metastasis by nigericin through inhibition of epithelial-mesenchymal transition. World J Gastroenterol. 2012 Jun 7;18(21):2640-8 4. Ju X, Zhu Y, Wang Y, et al. A novel cell culture system modeling the SARS-CoV-2 life cycle[J]. PLoS pathogens. 2021, 17(3): e1009439.

Citations

1. Ju X, Zhu Y, Wang Y, et al. A novel cell culture system modeling the SARS-CoV-2 life cycle. PLoS pathogens. 2021, 17(3): e1009439.

Related compound libraries

This product is contained In the following compound libraries：

Natural Product Library for HTS Immunology/Inflammation Compound Library Bioactive Compound Library Microbial Natural Product Library

Related Products

Related compounds with same targets

Protoanemonin (-)-α-Pinene Beta-mangostin Nanchangmycin Amikacin hydrate Sulfaclozine sodium Lenampicillin hydrochloride Cephradine monohydrate

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Keywords

Nigericin sodium salt 28643-80-3 NF-Kb信号通路离子通道免疫与炎症微生物学 Antibacterial Antibiotic NOD NOD-like Receptor (NLR) Potassium Channel Inhibitor Nigericin Bacterial inhibit KcsA inhibitor

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