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Nigericin sodium salt

Catalog No. T3092   CAS 28643-80-3

Nigericin sodium salt is an antibiotic from Streptomyces hygroscopicus and is a NLRP3 activator.Nigericin sodium is a cationic ionophore that inhibits Golgi function and suppresses growth of gram positive bacteria. It also prevents viral activation and triggers activation of the NALP3 inflammasome.

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Nigericin sodium salt Chemical Structure
Nigericin sodium salt, CAS 28643-80-3
Pack Size Availability Price/USD Quantity
1 mg In stock $ 31.00
5 mg In stock $ 72.00
10 mg In stock $ 122.00
25 mg In stock $ 209.00
50 mg In stock $ 312.00
100 mg In stock $ 468.00
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Purity: 99.52%
Purity: 99.05%
Purity: 98.2%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Nigericin sodium salt is an antibiotic from Streptomyces hygroscopicus and is a NLRP3 activator.Nigericin sodium is a cationic ionophore that inhibits Golgi function and suppresses growth of gram positive bacteria. It also prevents viral activation and triggers activation of the NALP3 inflammasome.
In vivo A 48-hr exposure of human erythrocytes to nigericin significantly increased the percentage of annexin-V-binding cells (0.1-10 nM), significantly decreased forward scatter (0.1-1 nM), significantly decreased cytosolic pH (0.1-1 nM) and significantly increased Fluo3 fluorescence (0.1-10 nM).?Nigericin (1 nM) slightly, but significantly, increased ROS, but did not significantly modify ceramide abundance.?The effect of nigericin on annexin V binding was significantly blunted, but not abolished by removal of extracellular Ca(2+).?The nigericin-induced increase in [Ca(2+)]i and annexin V binding was again significantly blunted but not abolished by the Na(+)/H(+) exchanger inhibitor cariporide (10 μM).?Nigericin triggers eryptosis, an effect paralleled by ROS formation, in part dependent on stimulation of Ca(2+) entry, and involving the cariporide-sensitive Na(+)/H(+) exchanger[1].
Molecular Weight 746.94
Formula C40H67NaO11
CAS No. 28643-80-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3mg/mL(4.02 mM), sonification is recommended.

Methanol: 122 mg/mL (163.33mM)

Ethanol: 47 mg/mL (62.92mM)

TargetMolReferences and Literature

1. Bissinger R, et al. Triggering of Suicidal Erythrocyte Death by the Antibiotic Ionophore Nigericin. Basic Clin Pharmacol Toxicol. 2016 May;118(5):381-9 2. Yakisich JS, et al. Nigericin decreases the viability of multidrug-resistant cancer cells and lung tumorspheres and potentiates the effects of cardiac glycosides. Tumour Biol. 2017 Mar;39(3):1010428317694310 3. Zhou HM, et al. Suppression of colorectal cancer metastasis by nigericin through inhibition of epithelial-mesenchymal transition. World J Gastroenterol. 2012 Jun 7;18(21):2640-8 4. Ju X, Zhu Y, Wang Y, et al. A novel cell culture system modeling the SARS-CoV-2 life cycle[J]. PLoS pathogens. 2021, 17(3): e1009439.

TargetMolCitations

1. Ju X, Zhu Y, Wang Y, et al. A novel cell culture system modeling the SARS-CoV-2 life cycle. PLoS pathogens. 2021, 17(3): e1009439.

Related compound libraries

This product is contained In the following compound libraries:
Microbial Natural Product Library Natural Product Library Pyroptosis Compound Library Anti-Infection Compound Library Anti-infective Natural Product Library Anti-Liver Cancer Compound Library Anti-Breast Cancer Compound Library Anti-Ovarian Cancer Compound Library Potassium Channel Blocker Library Covalent Inhibitor Library

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Keywords

Nigericin sodium salt 28643-80-3 Immunology/Inflammation Membrane transporter/Ion channel Microbiology/Virology NF-Κb Potassium Channel NOD-like Receptor (NLR) Antibacterial Antibiotic NOD Inhibitor Nigericin Bacterial inhibit Nigericin sodium KcsA inhibitor

 

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