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NU 9056

Catalog No. T23095 CAS 1450644-28-6

Synonyms: NU9056

NU 9056 is an effective and selective inhibitor of KAT5 histone acetyltransferase with an IC50 of 2 µM. NU 9056 blocks DNA damage response and inhibits protein acetylation in prostate cancer cell lines.

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NU 9056, CAS 1450644-28-6

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1 mg	In stock	$ 149.00

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Purity: 95.36%

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Description	NU 9056 is an effective and selective inhibitor of KAT5 histone acetyltransferase with an IC50 of 2 µM. NU 9056 blocks DNA damage response and inhibits protein acetylation in prostate cancer cell lines.
In vitro	NU 9056 shows IC50s of 60, 36, and >100 μM for KAT5, p300, pCAF and GCN5, respectively. In LNCaP cells, NU 9056 (17 µM, 24 µM, 36 µM) activates both caspase 3 and caspase 9 in a time- and concentration-dependent manner thereby inducing apoptosis. NU 9056 (2.5 µM, 5 µM, 10 µM, 20 µM, 40 µM) decreases the levels of acetylated histone H4K16, H3K14 and H4K8. NU 9056 causes a reduction of androgen receptor, prostate specific antigen, p53 and p21 protein levels[2].
In vivo	In mice, NU 9056 (2 μg/g) inhibits Tip60 and reduces H2A.Z binding at the the +1 nucleosome of Arc and Syp and the -1 nucleosome of Arc. NU 9056 increases the acetylation at the +1 nucleosome of Gria4 and the -1 nucleosome of Fos, Tacstd2, and Gria4[1].

Synonyms	NU9056
Molecular Weight	232.37
Formula	C6H4N2S4
CAS No.	1450644-28-6

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 112.5 mg/mL (484.1 mM), Sonification is recommended.

References and Literature

1. Klotilda Narkaj, et al. Blocking H2A.Z Incorporation via Tip60 Inhibition Promotes Systems Consolidation of Fear Memory in Mice. eNeuro. 2018 Nov 8;5(5):ENEURO.0378-18.2018. 2. Kelly Coffey, et al. Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer. PLoS One. 2012;7(10):e45539.

Citations

1. Chen G, Zhu X, Li J, et al. Celastrol inhibits lung cancer growth by triggering histone acetylation and acting synergically with HDAC inhibitors. Pharmacological Research. 2022: 106487

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Keywords

NU 9056 1450644-28-6 Chromatin/Epigenetic Histone Acetyltransferase NU-9056 NU9056 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.