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NAcM-OPT HCl(2089293-61-6 free base)

Catalog No. T9140 CAS 2416146-10-4

NAcM-OPT HCL is an orally bioavailable cullin neddylation 1 (DCN1) inhibitor that targets N-Acetyl-UBE2M (E2 conjugating enzyme, UBC12) interaction with DCN1 with IC50 of 79 nM.

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NAcM-OPT HCl(2089293-61-6 free base), CAS 2416146-10-4

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	NAcM-OPT HCL is an orally bioavailable cullin neddylation 1 (DCN1) inhibitor that targets N-Acetyl-UBE2M (E2 conjugating enzyme, UBC12) interaction with DCN1 with IC50 of 79 nM.
In vivo	NAcM-OPT is orally bioavailable, well tolerated in mice, and currently used to study the effects of acute pharmacologic inhibition of the DCN1-UBE2M interaction on the NEDD8/CUL pathway

Molecular Weight	470.86
Formula	C23H30Cl3N3O
CAS No.	2416146-10-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 60 mg/ml (127.43 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Hammill JT, et al. Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation. J Med Chem. 2018 Apr 12;61(7):2694-2706.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Ubiquitination Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets

NAcM-OPT HCl(2089293-61-6 free base) Pevonedistat NAcM-OPT TAS4464 hydrochloride

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

NAcM-OPT HCl(2089293-61-6 free base) 2416146-10-4 代谢 NEDD8 NAcMOPT HCl(2089293616 free base) NAcM OPT HCl(2089293 61 6 free base) Inhibitor inhibitor inhibit

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