Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NAcM-OPT HCL is an orally bioavailable cullin neddylation 1 (DCN1) inhibitor that targets N-Acetyl-UBE2M (E2 conjugating enzyme, UBC12) interaction with DCN1 with IC50 of 79 nM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 32.00 | |
5 mg | In stock | $ 47.00 | |
10 mg | In stock | $ 84.00 | |
25 mg | In stock | $ 151.00 | |
50 mg | In stock | $ 252.00 | |
100 mg | In stock | $ 412.00 | |
500 mg | In stock | $ 977.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 89.00 |
Description | NAcM-OPT HCL is an orally bioavailable cullin neddylation 1 (DCN1) inhibitor that targets N-Acetyl-UBE2M (E2 conjugating enzyme, UBC12) interaction with DCN1 with IC50 of 79 nM. |
In vivo | NAcM-OPT is orally bioavailable, well tolerated in mice, and currently used to study the effects of acute pharmacologic inhibition of the DCN1-UBE2M interaction on the NEDD8/CUL pathway |
Molecular Weight | 470.86 |
Formula | C23H30Cl3N3O |
CAS No. | 2416146-10-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/ml (127.43 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
NAcM-OPT HCl(2089293-61-6 free base) 2416146-10-4 Metabolism NEDD8 NAcMOPT HCl(2089293616 free base) NAcM OPT HCl(2089293 61 6 free base) inhibitor inhibit