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Macluraxanthone

Catalog No. TN5912 CAS 5848-14-6

Synonyms: 3-Hydroxyblancoxanthone

Macluraxanthone (3-Hydroxyblancoxanthone) has many biological activities including anticholinesterase, antioxidant, anticancer, antimalarial, anti-inflammatory and immunomodulatory effects. macluraxanthone promotes the polarization of M1-like pro-inflammatory macrophages by increasing the percentage of macrophages expressing CD86 while decreasing their expression of CD14, CD11b and CD80. Macluraxanthone significantly reduced the production of TNF-α and IL-10 cytokines in the presence of the pro-inflammatory stimulant lipopolysaccharide.

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Macluraxanthone, CAS 5848-14-6

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5 mg	Inquiry	$ 1,589.00
1 mL * 10 mM (in DMSO)	Inquiry	$ 1,898.00

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Description	Macluraxanthone (3-Hydroxyblancoxanthone) has many biological activities including anticholinesterase, antioxidant, anticancer, antimalarial, anti-inflammatory and immunomodulatory effects. macluraxanthone promotes the polarization of M1-like pro-inflammatory macrophages by increasing the percentage of macrophages expressing CD86 while decreasing their expression of CD14, CD11b and CD80. Macluraxanthone significantly reduced the production of TNF-α and IL-10 cytokines in the presence of the pro-inflammatory stimulant lipopolysaccharide.
In vitro	Macluraxanthone (3 and 10 μM), at non-toxic effective doses, significantly inhibited B16F10 cell invasion, to a greater extent than 10 μM doxorubicin, while reducing migration of cancer cells without cellular cytotoxicity. Our findings indicate for the first time that active macluraxanthone isolated from Maclura amboinensis Bl. roots affect multistep of cancer metastasis processes including proliferation, adhesion, invasion and migration, possibly through induction of apoptosis of highly metastatic B16F10 melanoma cells.[1]
In vivo	We investigated the in vivo therapeutic effects of the two xanthones in a xenograft murine model of human CLL, developed by engrafting CD5-transfected chronic leukemia B cells into SCID mice. Treatment of the animals with five daily injections of macluraxanthone (5 mg/kg) resulted in a significant prolongation of their survival as compared to control animals injected with the solvent alone (p = 0.0006 and p = 0.0141, respectively). These data show for the first time the in vivo antileukemic activities of two plant-derived xanthones.[2]

Synonyms	3-Hydroxyblancoxanthone
Molecular Weight	394.42
Formula	C23H22O6
CAS No.	5848-14-6

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store at low temperature,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Siripong P, et al. Anti-metastatic effects on B16F10 melanoma cells of extracts and two prenylated xanthones isolated from Maclura amboinensis Bl roots. Asian Pac J Cancer Prev. 2012;13(7):3519-3528. 2. Loisel S, et al. Therapeutic activity of two xanthones in a xenograft murine model of human chronic lymphocytic leukemia. J Hematol Oncol. 2010;3:49. 3. Khan MT, et al. Cholinesterase inhibitory activities of some flavonoid derivatives and chosen xanthone and their molecular docking studies. Chem Biol Interact. 2009;181(3):383-389. 4. Xiang Q, et al. Gerontoxanthone I and Macluraxanthone Induce Mitophagy and Attenuate Ischemia/Reperfusion Injury. Front Pharmacol. 2020;11:452. 5. Ng IMJ, et al. Immuno-modulatory effects of macluraxanthone on macrophage phenotype and function. Nat Prod Res. 2021;35(23):5409-5414.

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Keywords

Macluraxanthone 5848-14-6 Apoptosis oxidation-reduction TNF Antioxidant 3-Hydroxyblancoxanthone inhibitor inhibit

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