Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MI-1061 is a orally bioavailable inhibitor of MDM2 (MDM2-p53 interaction) (IC50=4.4 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,140.00 | |
50 mg | 6-8 weeks | $ 1,490.00 | |
100 mg | 6-8 weeks | $ 2,360.00 |
Description | MI-1061 is a orally bioavailable inhibitor of MDM2 (MDM2-p53 interaction) (IC50=4.4 nM). |
Targets&IC50 | MDM2:(ki)0.16 nM , MDM2:4.4 nM |
In vitro | MI-1061 achieves IC50 of 100 and 250 nM in the SJSA-1 and HCT-116 p53+/+ cell lines, respectively[1]. |
In vivo | MI-1061 was able to achieve tumor regression in oral SJSA-1 xenograft model mice[1]. |
Molecular Weight | 582.45 |
Formula | C30H26Cl2FN3O4 |
CAS No. | 1410737-34-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 300 mg/mL (515.07 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
MI-1061 1410737-34-6 Apoptosis Mdm2 MI1061 MI 1061 inhibitor inhibit