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M77976

Catalog No. T15944   CAS 394237-61-7

M77976 is a selective ATP-competitive inhibitor of pyruvate dehydrogenase kinase 4 (PDK4) with an inhibitory effect on PDK4, having an IC50 value of 648 μM. It is used for research related to obesity and diabetes.

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M77976 Chemical Structure
M77976, CAS 394237-61-7
Pack Size Availability Price/USD Quantity
1 mg In stock $ 43.00
5 mg In stock $ 98.00
10 mg In stock $ 183.00
25 mg In stock $ 329.00
50 mg In stock $ 538.00
100 mg In stock $ 913.00
500 mg In stock $ 1,820.00
1 mL * 10 mM (in DMSO) In stock $ 112.00
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Purity: 99.80%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description M77976 is a selective ATP-competitive inhibitor of pyruvate dehydrogenase kinase 4 (PDK4) with an inhibitory effect on PDK4, having an IC50 value of 648 μM. It is used for research related to obesity and diabetes.
Targets&IC50 PDK4:648 μM
In vitro Binding to the ATP-binding pocket of PDK4, M77976 induces local conformational changes, resulting in complete disordering of the ATP lid[1].
M77976 engages in hydrophobic interactions with the side chains of Asn258, Ala262, Val298, Leu306, and Thr358 of PDK4[1].
Molecular Weight 296.32
Formula C17H16N2O3
CAS No. 394237-61-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (337.47 mM), sonification is recommended.

TargetMolReferences and Literature

1. Kukimoto-Niino M, et al. Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4. Acta Crystallogr D Biol Crystallogr. 2011 Sep;67(Pt 9):763-73.

Related compound libraries

This product is contained In the following compound libraries:
Inhibitor Library

Related Products

Related compounds with same targets
PS210 JX06 PS10 BX795 PDK1-IN-RS2 Sodium dichloroacetate PDK4-IN-1 hydrochloride PHT-427

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Keywords

M77976 394237-61-7 PI3K/Akt/mTOR signaling PDK M-77976 M 77976 inhibitor inhibit

 

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