Powder: -20°C for 3 years | In solvent: -80°C for 1 year
M77976 is a selective ATP-competitive inhibitor of pyruvate dehydrogenase kinase 4 (PDK4) with an inhibitory effect on PDK4, having an IC50 value of 648 μM. It is used for research related to obesity and diabetes.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 43.00 | |
5 mg | In stock | $ 98.00 | |
10 mg | In stock | $ 183.00 | |
25 mg | In stock | $ 329.00 | |
50 mg | In stock | $ 538.00 | |
100 mg | In stock | $ 913.00 | |
500 mg | In stock | $ 1,820.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 112.00 |
Description | M77976 is a selective ATP-competitive inhibitor of pyruvate dehydrogenase kinase 4 (PDK4) with an inhibitory effect on PDK4, having an IC50 value of 648 μM. It is used for research related to obesity and diabetes. |
Targets&IC50 | PDK4:648 μM |
In vitro |
Binding to the ATP-binding pocket of PDK4, M77976 induces local conformational changes, resulting in complete disordering of the ATP lid[1]. M77976 engages in hydrophobic interactions with the side chains of Asn258, Ala262, Val298, Leu306, and Thr358 of PDK4[1]. |
Molecular Weight | 296.32 |
Formula | C17H16N2O3 |
CAS No. | 394237-61-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (337.47 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
M77976 394237-61-7 PI3K/Akt/mTOR signaling PDK M-77976 M 77976 inhibitor inhibit