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Larazotide acetate

Catalog No. T15711 CAS 881851-50-9

Larazotide acetate is a synthetic peptide. It functions as a tight junction regulator and reverses leaky junctions to their normally closed state.

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Larazotide acetate, CAS 881851-50-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 39.00
5 mg	In stock	$ 80.00
10 mg	In stock	$ 128.00
25 mg	In stock	$ 263.00
50 mg	In stock	$ 393.00
100 mg	In stock	$ 576.00

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Purity: 95.53%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Larazotide acetate is a synthetic peptide. It functions as a tight junction regulator and reverses leaky junctions to their normally closed state.
In vitro	Larazotide acetate inhibits the AT-1002-induced TEER reduction and TJ opening in Caco-2 cells and it also inhibits the redistribution and rearrangement of zonula occludens-1 (ZO-1) and actin caused by AT-1002 and gliadin fragments in Caco-2 and IEC6 cells. Larazotide acetate inhibits the translocation of a gliadin 13-mer peptide, which has been implicated in celiac disease, across Caco-2 cell monolayers. Apically applied Larazotide acetate inhibits the increase in TJ permeability elicited by basolaterally applied cytokines.
In vivo	Larazotide acetate inhibits gliadin-induced macrophage accumulation in the intestine and preserved normal tight junction structure when tested in vivo in gliadin-sensitized HLA-HCD4/DQ8 double transgenic mice.

Molecular Weight	785.89
Formula	C34H59N9O12
CAS No.	881851-50-9

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 16.67 mg/mL (21.21 mM), Sonification is recommended.

DMSO: 3.2 mg/mL (4.07 mM), Sonification and heating are recommended.

References and Literature

1. Gopalakrishnan S, et al. Larazotide acetate regulates epithelial tight junctions in vitro and in vivo. Peptides. 2012 May;35(1):86-94.

Related compound libraries

This product is contained In the following compound libraries：

Peptide Compound Library NO PAINS Compound Library Pediatric Drug Library Preclinical Compound Library

Related Products

Related compounds with same targets

TAT-Gap19 acetate Carbenoxolone Meclofenamic acid sodium Peptide5 TFA Carvedilol phosphate hemihydrate Gap19 Danegaptide Hydrochloride Meclofenamic acid

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Larazotide acetate 881851-50-9 Cytoskeletal Signaling Gap Junction Protein inhibit Larazotide Larazotide Acetate Inhibitor inhibitor

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