Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Larazotide acetate is a synthetic peptide. It functions as a tight junction regulator and reverses leaky junctions to their normally closed state.
Description | Larazotide acetate is a synthetic peptide. It functions as a tight junction regulator and reverses leaky junctions to their normally closed state. |
In vitro | Larazotide acetate inhibits the AT-1002-induced TEER reduction and TJ opening in Caco-2 cells and it also inhibits the redistribution and rearrangement of zonula occludens-1 (ZO-1) and actin caused by AT-1002 and gliadin fragments in Caco-2 and IEC6 cells. Larazotide acetate inhibits the translocation of a gliadin 13-mer peptide, which has been implicated in celiac disease, across Caco-2 cell monolayers. Apically applied Larazotide acetate inhibits the increase in TJ permeability elicited by basolaterally applied cytokines. |
In vivo | Larazotide acetate inhibits gliadin-induced macrophage accumulation in the intestine and preserved normal tight junction structure when tested in vivo in gliadin-sensitized HLA-HCD4/DQ8 double transgenic mice. |
Molecular Weight | 785.89 |
Formula | C34H59N9O12 |
CAS No. | 881851-50-9 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
H2O: 16.67 mg/mL (21.21 mM), Need ultrasonic
DMSO: 3.2 mg/mL (4.07 mM), Need ultrasonic and warming
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Larazotide acetate 881851-50-9 细胞骨架 Gap Junction Protein inhibit Larazotide Inhibitor inhibitor