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Larazotide acetate

Catalog No. T15711 CAS 881851-50-9

Larazotide acetate is a synthetic peptide. It functions as a tight junction regulator and reverses leaky junctions to their normally closed state.

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Larazotide acetate, CAS 881851-50-9

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Larazotide acetate is a synthetic peptide. It functions as a tight junction regulator and reverses leaky junctions to their normally closed state.
In vitro	Larazotide acetate inhibits the AT-1002-induced TEER reduction and TJ opening in Caco-2 cells and it also inhibits the redistribution and rearrangement of zonula occludens-1 (ZO-1) and actin caused by AT-1002 and gliadin fragments in Caco-2 and IEC6 cells. Larazotide acetate inhibits the translocation of a gliadin 13-mer peptide, which has been implicated in celiac disease, across Caco-2 cell monolayers. Apically applied Larazotide acetate inhibits the increase in TJ permeability elicited by basolaterally applied cytokines.
In vivo	Larazotide acetate inhibits gliadin-induced macrophage accumulation in the intestine and preserved normal tight junction structure when tested in vivo in gliadin-sensitized HLA-HCD4/DQ8 double transgenic mice.

Molecular Weight	785.89
Formula	C34H59N9O12
CAS No.	881851-50-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: 16.67 mg/mL (21.21 mM), Need ultrasonic

DMSO: 3.2 mg/mL (4.07 mM), Need ultrasonic and warming

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Gopalakrishnan S, et al. Larazotide acetate regulates epithelial tight junctions in vitro and in vivo. Peptides. 2012 May;35(1):86-94.

Related compound libraries

This product is contained In the following compound libraries：

Preclinical Compound Library Peptide Compound Library Drug Repurposing Compound Library Bioactive Compound Library Clinical Compound Library

Related Products

Related compounds with same targets

TAT-Gap19 acetate Gap19 Gap 27 Carbenoxolone Gap 26 Danegaptide Hydrochloride Rotigaptide TFA(355151-12-1 free base) Larazotide acetate

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Keywords

Larazotide acetate 881851-50-9 细胞骨架 Gap Junction Protein inhibit Larazotide Inhibitor inhibitor

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