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Itacitinib

Catalog No. T3998 CAS 1334298-90-6

Synonyms: INCB39110, INCB039110

Itacitinib (INCB039110) is an orally bioavailable inhibitor of Janus-associated kinase 1 (JAK1) with potential antineoplastic activity.

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Itacitinib, CAS 1334298-90-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 45.00
2 mg	In stock	$ 65.00
5 mg	In stock	$ 113.00
10 mg	In stock	$ 189.00
25 mg	In stock	$ 343.00
50 mg	In stock	$ 572.00
100 mg	In stock	$ 822.00
500 mg	In stock	$ 1,630.00
1 mL * 10 mM (in DMSO)	In stock	$ 139.00

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Purity: 99.01%

Purity: 97.57%

Purity: 96.4%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Itacitinib (INCB039110) is an orally bioavailable inhibitor of Janus-associated kinase 1 (JAK1) with potential antineoplastic activity.
In vitro	Itacitinib is an inhibitor of the Janus kinases (JAKs) with selectivity for JAK1.
In vivo	Itacitinib (INCB039110) produced significant improvements in sPGA, demonstrating proof of concept in chronic plaque psoriasis.

Synonyms	INCB39110, INCB039110
Molecular Weight	553.51
Formula	C26H23F4N9O
CAS No.	1334298-90-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (108.4 mM)

References and Literature

1. Bissonnette R, et al. A randomized, double-blind, placebo-controlled, dose-escalation study of the safety and efficacy of INCB039110, an oral janus kinase 1 inhibitor, in patients with stable, chronic plaque psoriasis. J Dermatolog Treat. 2016 Aug;27(4):332-8. 2. Zhang Y, et al. Impact on creatinine renal clearance by the interplay of multiple renal transporters: a case study with INCB039110. Drug Metab Dispos. 2015 Apr;43(4):485-9. 3. Chen C, Lu M, Lin S, et al. The nuclear gene rpl18 regulates erythroid maturation via JAK2-STAT3 signaling in zebrafish model of Diamond–Blackfan anemia[J]. Cell Death & Disease. 2020, 11(2): 1-11.

Citations

1. Chen C, Lu M, Lin S, et al. The nuclear gene rpl18 regulates erythroid maturation via JAK2-STAT3 signaling in zebrafish model of Diamond–Blackfan anemia. Cell Death & Disease. 2020, 11(2): 1-11 2. Zhao C, Ma Y, Zhang M, et al.Polyamine metabolism controls B-to-Z DNA transition to orchestrate DNA sensor cGAS activity.Immunity.2023

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Anti-Cancer Active Compound Library Inhibitor Library Anti-Aging Compound Library NO PAINS Compound Library Reprogramming Compound Library Stem Cell Differentiation Compound Library

Related Products

Related compounds with same targets

Ginsenoside Rk1 JAK-IN-10 NVP-BSK805 2HCl (1092499-93-8(free base)) Gusacitinib JAK-IN-25 SB1317 hydrochloride (1204918-72-8(free base)) Oclacitinib maleate WHI-P258

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Itacitinib 1334298-90-6 Angiogenesis Chromatin/Epigenetic JAK/STAT signaling Stem Cells JAK inhibit Janus kinase INCB 039110 INCB39110 INCB 39110 INCB039110 INCB-039110 INCB-39110 Inhibitor inhibitor

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