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Insulin (human)

Catalog No. T8221 CAS 11061-68-0

Synonyms: INSULIN, Insulin(human)

Insulin (human) is a peptide hormone that promotes glycogen synthesis and regulates glucose levels in the blood. Insulin (human) has hypoglycemic activity and is used clinically to treat hyperglycemia in diabetic patients.

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Insulin (human), CAS 11061-68-0

Pack Size	Availability	Price/USD
5 mg	In stock	$ 30.00
10 mg	In stock	$ 40.00
25 mg	In stock	$ 62.00
50 mg	In stock	$ 78.00
100 mg	In stock	$ 97.00
200 mg	In stock	$ 138.00
500 mg	In stock	$ 233.00

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Purity: 99.34%

Purity: 99.23%

Purity: 98.09%

Purity: 97.32%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Insulin (human) is a peptide hormone that promotes glycogen synthesis and regulates glucose levels in the blood. Insulin (human) has hypoglycemic activity and is used clinically to treat hyperglycemia in diabetic patients.
In vitro	METHODS: Neonatal rat cardiomyocyte NRCMs were incubated with Insulin (100 nM) for 48 h, and the expression levels of target proteins were detected using Western Blot. RESULTS: PE+Insulin treatment resulted in a slight decrease in relative hypertrophic protein levels compared to the PE group. TAC+GAS+Insulin induced a decrease in hypertrophy-associated proteins compared with the TAC+GAS group, and Insulin enhanced the protective effect of GAS against cardiac hypertrophy. [1] METHODS: Bovine aortic endothelial cells bAECs were incubated with Insulin (100 nM) for 10-50 min, and the expression levels of target proteins were detected using the Immunoprecipitation method. RESULTS: Insulin stimulated the phosphorylation of IRβ Tyr within 10 min, reached a maximum at 30 min, and decreased thereafter. [2] METHODS: Vascular smooth muscle cells CVSMCs were treated with Insulin (1-100 nM) for 48 h. RANKL expression was detected by qRT-PCR. RESULTS: 1 nM Insulin had no effect on RANKL mRNA expression. 5 nM Insulin stimulation resulted in a significant increase in RANKL mRNA levels, and 10 nM Insulin had the greatest effect on RANKL mRNA expression levels. At significantly supraphysiologic insulin concentrations, RANKL mRNA levels decreased slightly compared to the maximal effect of Insulin. [3]
In vivo	METHODS: To test the antitumor activity in vivo, Insulin (0.035 mg per mouse) and anti-PD1 (0.25 mg per mouse) were intraperitoneally injected into C57BL/6 mice bearing mouse colorectal carcinoma tumor MC38 every two days for five administrations. RESULTS: anti-PD1 significantly inhibited the growth of MC38 tumors, while Insulin promoted the growth of MC38 tumors. The therapeutic effect of the combination of Insulin and anti-PD1 on MC38 tumor suppression was attenuated compared to anti-PD1 treatment alone. anti-PD1 significantly increased the number of infiltrating CD8+ T cells, whereas Insulin significantly decreased the number of tumor-infiltrating CD8+ T cells. [4] METHODS: To study virus-induced insulin-dependent diabetes mellitus (IDDM), Insulin (1 mg) was administered orally to RIP-LCMV tg mice twice a week for two months. RESULTS: Insulin treatment was effective in preventing the progression of islet infiltration to overt IDDM in pre-diabetic tg mice. Oral administration of Insulin did not affect the production of LCMV-NP-specific anti auto-cytotoxic T lymphocytes or the infiltration of lymphocytes into the pancreas. [5]

Synonyms	INSULIN, Insulin(human)
Molecular Weight	5807.57
Formula	C257H383N65O77S6
CAS No.	11061-68-0

Storage

store at low temperature,keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 16.6 mg/mL (2.86 mM), when pH is adjusted to 2-3 with HCl. Sonification and heating are recommended.

References and Literature

1. Zhang M, et al. GLUT4 mediates the protective function of gastrodin against pressure overload-induced cardiac hypertrophy. Biomed Pharmacother. 2023 May;161:114324. 2. Li G, et al. Insulin at physiological concentrations selectively activates insulin but not insulin-like growth factor I (IGF-I) or insulin/IGF-I hybrid receptors in endothelial cells. Endocrinology. 2005 Nov;146(11):4690-6. 3. Yuan LQ, et al. RANKL is a downstream mediator for insulin-induced osteoblastic differentiation of vascular smooth muscle cells. PLoS One. 2011;6(12):e29037. 4. Zhan ZT, et al. The Effects of 6 Common Antidiabetic Drugs on Anti-PD1 Immune Checkpoint Inhibitor in Tumor Treatment. J Immunol Res. 2022 Aug 18;2022:2651790. 5. von Herrath MG, et al. Oral insulin treatment suppresses virus-induced antigen-specific destruction of beta cells and prevents autoimmune diabetes in transgenic mice. J Clin Invest. 1996 Sep 15;98(6):1324-31.

Citations

1. Zhang M, Tan Y, Song Y, et al.GLUT4 mediates the protective function of gastrodin against pressure overload-induced cardiac hypertrophy.Biomedicine & Pharmacotherapy.2023, 161: 114324. 2. Chen S, Zhou X, Li W, et al.Development of a novel peptide targeting GPR81 to suppress adipocyte-mediated tumor progression.Biochemical Pharmacology.2023: 115800. 3. Zhou J, Shi Y, Yang C, et al.γ-glutamylcysteine alleviates insulin resistance and hepatic steatosis by regulating adenylate cyclase and IGF-1R/IRS1/PI3K/Akt signaling pathways.The Journal of Nutritional Biochemistry.2023: 109404. 4. Liu Y, Li Y, Liang J, et al. The Mechanism of Leptin on Inhibiting Fibrosis and Promoting Browning of White Fat by Reducing ITGA5 in Mice. International Journal of Molecular Sciences. 2021, 22(22): 12353. 5. Zhan Z T, Liu L, Cheng M Z, et al. The Effects of 6 Common Antidiabetic Drugs on Anti-PD1 Immune Checkpoint Inhibitor in Tumor Treatment. Journal of Immunology Research. 2022

Related compound libraries

This product is contained In the following compound libraries：

Peptide Compound Library

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Keywords

Insulin (human) 11061-68-0 Tyrosine Kinase/Adaptors IGF-1R INSULIN Insulin Receptor Inhibitor Insulin Insulin(human) inhibit inhibitor

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