Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Helenalin is a selective inhibitor of transcription factor NF-κB by direct targeting of p65. It is an anti-inflammatory sesquiterpene lactone compound with alkylating activity. Through its ability to target the cysteine sulfhydryl groups in the p65 subunit of NF-κB, helenalin effectively inhibits its DNA binding.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | 35 days | $ 1,260.00 |
Description | Helenalin is a selective inhibitor of transcription factor NF-κB by direct targeting of p65. It is an anti-inflammatory sesquiterpene lactone compound with alkylating activity. Through its ability to target the cysteine sulfhydryl groups in the p65 subunit of NF-κB, helenalin effectively inhibits its DNA binding. |
In vitro | After 80 minutes, Helenalin (10 μM; 20-120 minutes) induces complete inhibition of NF-κB DNA binding [1]. Helenalin, the anti-inflammatory and anti-carcinogenic phytochemicals, is an effective inhibitor of periodic Skp2 accumulation which is an F-box protein mediating SCF E3 ligase ubiquitylation and degradation of both CKIs during S phase progression[3]. |
In vivo | To immature male ICR mice, Helenalin (25 mg/kg; i.p.; 6 to 12 hours) administers, induced a rapid reduction in hepatic glutathione levels[2]. |
Molecular Weight | 262.3 |
Formula | C15H18O4 |
CAS No. | 6754-13-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Helenalin 6754-13-8 Others inhibitor inhibit