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Golotimod hydrochloride (229305-39-9 free base)

Catalog No. T11449 CAS T11449

Synonyms: Golotimod hydrochloride, Gamma-D-glutamyl-L-tryptophan hydrochloride, SCV 07 hydrochloride

Golotimod hydrochloride (SCV 07 hydrochloride) is an immunomodulating peptide with antimicrobial properties. It enhances antituberculosis therapy effectiveness, promotes thymic and splenic cell proliferation, and boosts macrophage functionality. Furthermore, it inhibits STAT3 signaling, thereby modifying the duration and intensity of oral mucositis in animal models subjected to radiation or a combination of radiation and Cisplatin. Additionally, Golotimod hydrochloride has shown potential as a treatment for recurrent genital herpes simplex virus type 2 (HSV-2) [1] [2] [3].

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Golotimod hydrochloride (229305-39-9 free base) Chemical Structure

Golotimod hydrochloride (229305-39-9 free base), CAS T11449

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Biological Description

Chemical Properties

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Description

In vitro

Golotimod hydrochloride is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2) [1]. Golotimod inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin [2].

Synonyms	Golotimod hydrochloride, Gamma-D-glutamyl-L-tryptophan hydrochloride, SCV 07 hydrochloride
Molecular Weight	369.8
Formula	C16H20ClN3O5
CAS No.	T11449

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 125 mg/mL (338.02 mM), Sonification is recommended.

References and Literature

1. Rose WA 2nd, et al. An immunomodulating dipeptide, SCV-07, is a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2). Int J Antimicrob Agents. 2008 Sep;32(3):262-6. 2. Geiger JL, et al. The STAT3 pathway as a therapeutic target in head and neck cancer: Barriers and innovations. Oral Oncol. 2016 May;56:84-92. 3. Watkins B, et al. Attenuation of radiation- and chemoradiation-induced mucositis using gamma-D-glutamyl-L-tryptophan (SCV-07). Oral Dis. 2010 Oct;16(7):655-60.

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Keywords

Golotimod hydrochloride (229305-39-9 free base) T11449 JAK/STAT signaling Stem Cells STAT SCV07 Hydrochloride Golotimod hydrochloride (229305 39 9 free base) Golotimod hydrochloride SCV-07 Hydrochloride Gamma-D-glutamyl-L-tryptophan Hydrochloride Gamma-D-glutamyl-L-tryptophan hydrochloride 229305-39-9 SCV 07 hydrochloride 229305-39-9 free base SCV 07 Hydrochloride Golotimod Hydrochloride Golotimod hydrochloride (229305399 free base) inhibitor inhibit

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