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Gentamicin sulfate

Catalog No. T1326 CAS 1405-41-0

Synonyms: Gentamycin sulfate, SCH9724, NSC-82261

Gentamycin Sulfate is a wide-spectrum, aminoglycoside <a href="/target/Antibiotic" style="display: inline; color: #c13a36">Antibiotic</a> used to inhibit protein synthesis in sensitive organisms.

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Gentamicin sulfate, CAS 1405-41-0

Pack Size	Availability	Price/USD
100 mg	In stock	$ 35.00
200 mg	In stock	$ 42.00
500 mg	In stock	$ 53.00
1 g	In stock	$ 72.00

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Purity: 651u/mg

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Gentamycin Sulfate is a wide-spectrum, aminoglycoside antibiotic used to inhibit protein synthesis in sensitive organisms.
Targets&IC50	DNase I:0.57 mM
In vivo	Gentamicin is the first choice aminoglycoside for the treatment of serious infections at present, with alternatives being amikacin, netilmicin, and tobramycin. Gentamicin preparations are commercially available in three forms, namely otic, ophthalmic, and topical based on the respective function to treat infections of ear canal, eye, and skin. Oral and injectable forms of gentamicin are found to exhibit effective antibacterial activity against Yersinia pestis as demonstrated in a mouse infection model[4]. Treatment with up to nine doses of methicillin or gentamicin shows an obvious reduction of bacteria on the foreign body[5].

Synonyms	Gentamycin sulfate, SCH9724, NSC-82261
Molecular Weight	575.68
Formula	C21H45N5O11S
CAS No.	1405-41-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: Insoluble

H2O: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Martin NL, et al. Antimicrob Agents Chemother. 1986 Jun;29(6):1079-87. 2. Kadurugamuwa JL, et al. J Bacteriol. 1993 Sep;175(18):5798-805. 3. Montenez JP, et al. Toxicol Lett. 1994 Sep;73(3):201-8. 4. Kumar CG, et al. Microbial biosynthesis and applications of gentamicin: a critical appraisal. 5. Espersen F, et al. Effect of treatment with methicillin and gentamicin in a new experimental mouse model of foreignbody infection. Antimicrob Agents Chemother. 1994 Sep;38(9):2047-53. 6. Xu W, et al. A rapid and sensitive method for kinetic study and activity assay of DNase I in vitro based on a GO-quenched hairpin probe. Anal Bioanal Chem. 2016 May;408(14):3801-9.

Related compound libraries

This product is contained In the following compound libraries：

FDA-Approved & Pharmacopeia Drug Library DNA Damage & Repair Compound Library Antibiotics Library Inhibitor Library Anti-Metabolism Disease Compound Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Orally Active Compound Library Anti-Cancer Compound Library Anti-Bacterial Compound Library

Related Products

Related compounds with same targets

Amikacin sulfate Acetylspiramycin Gentamicin sulfate Chlortetracycline hydrochloride Lincomycin hydrochloride Roxithromycin Clindamycin phosphate Tetracycline

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Gentamicin sulfate 1405-41-0 Cell Cycle/Checkpoint DNA Damage/DNA Repair Metabolism Microbiology/Virology ribosome Antibacterial DHFR Antibiotic Bacterial Gentamicin Inhibitor inhibit Meniere’s disease orally active Gentamycin sulfate glandular tularemia SCH9724 NSC-82261 inhibitor

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