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GPR120 Agonist 3

Catalog No. T15413 CAS 1599477-75-4

Synonyms: GPR120-IN-1

GPR120 Agonist 3 (GPR120-IN-1) is a selective agonist of Gpr120 ( logEC50: -7.62).

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GPR120 Agonist 3, CAS 1599477-75-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 35.00
2 mg	In stock	$ 50.00
5 mg	In stock	$ 81.00
10 mg	In stock	$ 147.00
25 mg	In stock	$ 289.00
50 mg	In stock	$ 413.00
100 mg	In stock	$ 619.00
1 mL * 10 mM (in DMSO)	In stock	$ 89.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	GPR120 Agonist 3 (GPR120-IN-1) is a selective agonist of Gpr120 ( logEC50: -7.62).
Targets&IC50	GPR120:−7.62 (logEC50)
In vitro	GPR120-IN-1 causes a concentration-dependent response to recruiting β-arrestin-2 in both human and mouse Gpr120 expressing cells(EC50s: ~0.35 μM). GPR120-IN-1 produces concentration-dependent increases in IP3 production from both human and mouse Gpr120 expressing cells. GPR120-IN-1 strongly and comparably inhibits LPS-induced phosphorylation of Ikkβ, Tak1, and Jnk and blocked IκB degradation.
In vivo	GPR120-IN-1 treatment has beneficial effects on hepatic lipid metabolism. It causes decreased liver triglycerides, decreased hepatic steatosis, and DAGs, as well as decreased saturated free fatty acid content. GPR120-IN-1 causes improved insulin sensitivity with increased glucose infusion rates. It also enhanced the insulin stimulated-glucose disposal rate. Only in WT mice, along with a marked increase in the ability of insulin to suppress hepatic glucose production.

Synonyms	GPR120-IN-1
Molecular Weight	405.84
Formula	C19H23ClF3NO3
CAS No.	1599477-75-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (123.20 mM)

H2O: < 0.1 mg/mL (insoluble), Sonication and heating to 60℃ are recommended.

References and Literature

1. Oh DY, et al. A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice. Nat Med. 2014 Aug;20(8):942-7.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library GPCR Compound Library Bioactive Compounds Library Max Endocrinology-Hormone Compound Library Bioactive Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

GPR120 Agonist 3 1599477-75-4 Endocrinology/Hormones GPCR/G Protein GPR FFAR GPR120-IN-1 Free Fatty Acid Receptor inhibit Inhibitor GPR-120 Agonist 3 inhibitor

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