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Finrozole

Catalog No. T27320 CAS 160146-17-8

Synonyms: MPV 2213ad, MPV-2213ad, MPV 2213, MPV-2213, MPV2213ad

Finrozole (MPV 2213ad) is a novel selective aromatase inhibitor that is partially reversible for breast development.

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Finrozole, CAS 160146-17-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 130.00
5 mg	In stock	$ 320.00
10 mg	In stock	$ 480.00
25 mg	In stock	$ 786.00
50 mg	In stock	$ 1,080.00
100 mg	In stock	$ 1,480.00
500 mg	In stock	$ 2,960.00

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Purity: 100%

Biological Description

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Description

Finrozole (MPV 2213ad) is a novel selective aromatase inhibitor that is partially reversible for breast development.

In vivo

To investigate the pharmacokinetics of finrozole (MPV-2213ad), a novel competitive aromatase enzyme inhibitor, in healthy male volunteers. METHODS: The study was an open, partly randomized cross-over study including 23 volunteers receiving single doses of 3, 9 mg, or 30 mg of finrozole as tablets or solution with 14 days between the administrations. The highest dose was given as tablets only. Serum concentrations of finrozole were determined using high performance liquid chromatography combined with mass spectrometry. RESULTS: The mean time to peak serum concentration ranged from 2.5 to 3.1, and 0.6-0.7 h after tablets and solution, respectively. The Cmax values increased as the dose increased. The calculated apparent mean elimination half-life (t(1/2,z)) was approximately 3 h after the solution, and approximately 8 h after the tablet. The AUC(0, infinity) after finrozole tablets increased proportionally from 3 mg to 9 mg and from 3 to 30 mg. The calculated relative mean bioavailabilities (AUC(0, infinity)-ratio) for the 3 mg and 9 mg doses of finrozole as tablets were 89% and 78%, respectively. CONCLUSIONS: The absorption of finrozole from the tablet formulation was relatively rapid, and the apparent elimination half-life was longer after the tablet than after the solution, probably reflecting the overlap of the absorption with the elimination phase.[1]

Synonyms	MPV 2213ad, MPV-2213ad, MPV 2213, MPV-2213, MPV2213ad
Molecular Weight	322.34
Formula	C18H15FN4O
CAS No.	160146-17-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Ahokoski O, et al. Pharmacokinetics of finrozole (MPV-2213ad), a novel selective aromatase inhibitor, in healthy men. Br J Clin Pharmacol. 2001 Dec;52(6):702-4. 2. Streng T, et al. Developmental, estrogen induced infravesical obstruction is reversible in adult male rodents. J Urol. 2002 Nov;168(5):2263-8. 3. Lindh L, et al. Administration of aromatase inhibitor MPV-2213ad to blue fox vixens (Vulpes lagopus) as a model for contraception in female dogs. Theriogenology. 2020 Aug;152:53-63. 4. Storvik M, et al. Aflatoxin B1--a potential endocrine disruptor--up-regulates CYP19A1 in JEG-3 cells. Toxicol Lett. 2011 May 10;202(3):161-7.

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Keywords

Finrozole 160146-17-8 Endocrinology/Hormones Aromatase MPV 2213ad MPV2213 MPV-2213ad MPV 2213 MPV-2213 MPV2213ad inhibitor inhibit

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