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Epiberberine chloride

Epiberberine chloride
Epiberberine chloride, a natural pro-berberine from Coptis chinensis Franch. is an AChE, BChE, and BACE1 inhibitor with IC50 values of 1.07, 6.03, and 8.55 μM, respectively.Epiberberine chloride has antioxidant effects and inhibits the effects of Ca9-22 and Fa2R. Epiberberine chloride has antioxidant effects, inhibits the motility of Ca9-22 and FaDu cell lines, and can be used to study hyperlipidemia, Alzheimer's disease and diabetes.
Catalog No. T8306Cas No. 889665-86-5
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Purity:99.89%
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Epiberberine chloride

Catalog No. T8306Cas No. 889665-86-5
Epiberberine chloride, a natural pro-berberine from Coptis chinensis Franch. is an AChE, BChE, and BACE1 inhibitor with IC50 values of 1.07, 6.03, and 8.55 μM, respectively.Epiberberine chloride has antioxidant effects and inhibits the effects of Ca9-22 and Fa2R. Epiberberine chloride has antioxidant effects, inhibits the motility of Ca9-22 and FaDu cell lines, and can be used to study hyperlipidemia, Alzheimer's disease and diabetes.
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Pack SizePriceAvailabilityQuantity
1 mg$32In Stock
5 mg$73In Stock
10 mg$98In Stock
25 mg$198In Stock
50 mg$298In Stock
100 mg$443In Stock
1 mL x 10 mM (in DMSO)$80In Stock
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Product Introduction

Bioactivity
Description
Epiberberine chloride, a natural pro-berberine from Coptis chinensis Franch. is an AChE, BChE, and BACE1 inhibitor with IC50 values of 1.07, 6.03, and 8.55 μM, respectively.Epiberberine chloride has antioxidant effects and inhibits the effects of Ca9-22 and Fa2R. Epiberberine chloride has antioxidant effects, inhibits the motility of Ca9-22 and FaDu cell lines, and can be used to study hyperlipidemia, Alzheimer's disease and diabetes.
Targets&IC50
BChE:6.03 µM, BACE1:8.55 μM, AChE:1.07 µM
In vitro
Epiberberine chloride has antioxidant activity, with peroxynitrite ONOO- scavenging effect (IC50, 16.83 μM), and may protect against Alzheimer disease[1]. Epiberberine (0, 12.5, 25, or 50 μM) dose-dependently inhibits cellular triglyceride accumulation in 3T3-L1 adipocytes (IC50: 52.8 μM). Epiberberine (12.5-50 μM) suppresses the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways in the early stage of 3T3-L1 adipocyte differentiation [2]. Epiberberine (0.2, 1, 5 μg/mL) inhibits glucose uptake in HepG2 cells in a concentration-dependent manner [3].
In vivo
Body weight, food consumption, water intake, and urinary output of KK-Ay mice were reduced after being treated with Epiberberine (225 mg/kg, p.o. daily for 40 days).
Chemical Properties
Molecular Weight371.81
FormulaC20H18ClNO4
Cas No.889665-86-5
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 20 mg/mL (53.80 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6895 mL13.4477 mL26.8955 mL134.4773 mL
5 mM0.5379 mL2.6895 mL5.3791 mL26.8955 mL
10 mM0.2690 mL1.3448 mL2.6895 mL13.4477 mL
20 mM0.1345 mL0.6724 mL1.3448 mL6.7239 mL
50 mM0.0538 mL0.2690 mL0.5379 mL2.6895 mL

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