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DBCO-PEG4-NHS ester

Name: DBCO-PEG4-NHS ester
Brand: TargetMol
SKU: T15073
Price: 89 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T15073 Copy Product Info

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DBCO-PEG4-NHS ester is a PEG-based PROTAC linker utilized in PROTAC synthesis[1].

DBCO-PEG4-NHS ester

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Catalog No. T15073

DBCO-PEG4-NHS ester is a PEG-based PROTAC linker utilized in PROTAC synthesis[1].

Cas No. 1427004-19-0

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Pack Size	Price	USA Stock	Global Stock
5 mg	$31	In Stock	In Stock
10 mg	$51	In Stock	In Stock
25 mg	$89	In Stock	In Stock
50 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$52	-	In Stock

In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:≥98%

Appearance:Oil

Color:Yellow

Resource Download

COA HNMR

Product Introduction

Bioactivity

Description	DBCO-PEG4-NHS ester is a PEG-based PROTAC linker utilized in PROTAC synthesis[1].
In vitro	PROTACs consist of two ligands linked together: one ligand targets an E3 ubiquitin ligase, and the other targets the specific protein. They utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1].

Chemical Properties

Molecular Weight	649.69
Formula	C₃₄H₃₉N₃O₁₀
Cas No.	1427004-19-0
Smiles	O=C(CCC(=O)N1Cc2ccccc2C#Cc2ccccc12)NCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O
Relative Density.	1.33 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 79 mg/mL (121.6 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.08 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5392 mL	7.6960 mL	15.3920 mL	76.9598 mL
5 mM	0.3078 mL	1.5392 mL	3.0784 mL	15.3920 mL
10 mM	0.1539 mL	0.7696 mL	1.5392 mL	7.6960 mL
20 mM	0.0770 mL	0.3848 mL	0.7696 mL	3.8480 mL
50 mM	0.0308 mL	0.1539 mL	0.3078 mL	1.5392 mL
100 mM	0.0154 mL	0.0770 mL	0.1539 mL	0.7696 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc