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D4-abiraterone

Catalog No. T10946   CAS 154229-21-7
Synonyms: Abiraterone D4A metabolite, CB-7627, Δ4-Abiraterone

D4-Abiraterone is an inhibitor of CYP17A1, 3b-hydroxysteroid dehydrogenase (3βHSD) and steroid 5a-reductase (SRD5A), the main metabolite of abiraterone. D4-Abiraterone is also an antagonist of androgen receptor.

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D4-abiraterone Chemical Structure
D4-abiraterone, CAS 154229-21-7
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Biological Description
Chemical Properties
Storage & Solubility Information
Description D4-Abiraterone is an inhibitor of CYP17A1, 3b-hydroxysteroid dehydrogenase (3βHSD) and steroid 5a-reductase (SRD5A), the main metabolite of abiraterone. D4-Abiraterone is also an antagonist of androgen receptor.
Synonyms Abiraterone D4A metabolite, CB-7627, Δ4-Abiraterone
Molecular Weight 347.49
Formula C24H29NO
CAS No. 154229-21-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (143.89 mM), sonification is recommended.

TargetMolReferences and Literature

1. Li Z, et al. Conversion of abiraterone to D4A drives anti-tumour activity in prostate cancer. Nature. 2015 Jul 16;523(7560):347-51.

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Keywords

D4-abiraterone 154229-21-7 Endocrinology/Hormones Androgen Receptor Abiraterone D4A metabolite CB-7627 CB7627 CB 7627 D4abiraterone D-4-abiraterone Δ4-Abiraterone D4 abiraterone delta4-Abiraterone inhibitor inhibit

 

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