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Clofazimine

Catalog No. T0377 CAS 2030-63-9

Synonyms: NSC-141046, 氯苯吩嗪, 氯法齐明

Clofazimine is a phenazine dye with anti-mycobacterial and anti-inflammatory activities. Clofazimine has a slow bactericidal effect on Mycobacterium leprae and is active against various other Mycobacteria.

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Clofazimine, CAS 2030-63-9

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	NSC-141046, 氯苯吩嗪, 氯法齐明
Molecular Weight	473.4
Formula	C27H22Cl2N4
CAS No.	2030-63-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: <1 mg/mL

Ethanol: <1 mg/mL

DMSO: 5 mg/mL (10.56 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Arbiser JL, et al. J Am Acad Dermatol, 1995, 32(2 Pt 1), 241-247. 2. Van Rensburg CE, et al. Antimicrob Agents Chemother, 1992, 36(12), 2729-2735. 3. Reddy VM, et al. Antimicrob Agents Chemother, 1996, 40(3), 633-636. 4. Adams LB, et al. Antimicrob Agents Chemother, 1999, 43(7), 1638-1643. 5. Peters K, et al. J Antimicrob Chemother, 2000, 45(1), 77-83. 6. Bowden G D, Land K M, O'Connor R M, et al. High-throughput screen of drug repurposing library identifies inhibitors of Sarcocystis neurona growth[J]. International Journal for Parasitology: Drugs and Drug Resistance. 2018 Apr；8(1): 137-144.

Citations

1. Bowden G D, Land K M, O'Connor R M, et al. High-throughput screen of drug repurposing library identifies inhibitors of Sarcocystis neurona growth. International Journal for Parasitology: Drugs and Drug Resistance. 2018 Apr；8(1): 137-144

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Anti-Lung Cancer Compound Library Anti-Obesity Compound Library Antibiotics Library Inhibitor Library Drug-induced Liver Injury (DILI) Compound Library DNA Damage & Repair Compound Library Immunology/Inflammation Compound Library Anti-Metabolism Disease Compound Library Drug Repurposing Compound Library

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Clofazimine 2030-63-9 DNA损伤和修复微生物学 Antibacterial Antibiotic DNA Inhibitor Bacterial inhibit NSC-141046 inhibitor

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