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C75
🥰Excellent
Catalog No. T10657Cas No. 218137-86-1
Alias C-75
C75 is an inhibitor synthetic fatty-acid synthase (FASN) and inhibits prostate cancer cells PC3 (IC50: 35 μM).C75 increases CPT1 activity and reduces DIO.
C75
🥰Excellent
Purity: 100%
Catalog No. T10657Alias C-75Cas No. 218137-86-1
C75 is an inhibitor synthetic fatty-acid synthase (FASN) and inhibits prostate cancer cells PC3 (IC50: 35 μM).C75 increases CPT1 activity and reduces DIO.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $41 | In Stock | |
| 2 mg | $59 | In Stock | |
| 5 mg | $98 | In Stock | |
| 10 mg | $165 | In Stock | |
| 25 mg | $332 | In Stock | |
| 50 mg | $530 | In Stock | |
| 100 mg | $840 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $108 | In Stock |
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Purity:100%
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Product Introduction
Bioactivity
Chemical Properties
| Description | C75 is an inhibitor synthetic fatty-acid synthase (FASN) and inhibits prostate cancer cells PC3 (IC50: 35 μM).C75 increases CPT1 activity and reduces DIO. |
| Targets&IC50 | OVCAR-3 cells:21.9 μM, LNCaP cells:50 μM, MCF7 cells:27.3 μM, SK-BR-3 cells:19.8 μM, MIA PaCa-2 cells:21.8 μM, PC3 cells:35 μM, MDA-MB-231 cells:43.8 μM, Fibroblast:63.2 μM, HCT-116 cells:46.4 μM |
| In vitro | C75 (10-50 μM) reduces the growth of LNCaP spheroids in a concentration-dependent manner (IC50: 50 μM). (-)-C75 inhibits FAS activity and has a cytotoxic effect on tumor cell lines, without affecting food consumption. (+)-C75 inhibits CPT1 and produces anorexia. The differential activity of C75 enantiomers may lead to the development of potential new specific drugs for cancer and obesity [2]. |
| In vivo | C75 (i.p.) blocks fasting-induced c-Fos expression in the arcuate nucleus, lateral hypothalamic area, and paraventricular nucleus. C75 (30 mg/kg, i.p.) inhibits the food intake of mice by ≥95% within 2 h[3]. C75-treated DIO mice have a 50% greater weight loss, and a 32.9% increased production of energy because of fatty acid oxidation. C75 treatment of rodent adipocytes and hepatocytes and human breast cancer cells increases fatty acid oxidation and ATP levels by increasing CPT-1 activity, even in the presence of elevated concentrations of malonyl-CoA [4]. |
| Alias | C-75 |
| Molecular Weight | 254.32 |
| Formula | C14H22O4 |
| Cas No. | 218137-86-1 |
| Smiles | CCCCCCCCC1OC(=O)C(=C)C1C(O)=O |
| Relative Density. | 1.08 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 75.6 mg/mL (297.26 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 0.5% CMC-Na: 5 mg/mL (19.66 mM), Suspension. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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