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C75

Name: C75
Brand: TargetMol
SKU: T10657
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: C-75) Copy Product Info

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Synonyms: C-75

Catalog No. T10657 Copy Product Info

Purity: 98.84%

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C75 is a fatty acid synthase (FASN) inhibitor (IC50 = 35 μM in PC3 cells) with cell permeability and the ability to activate CPT1A. This compound possesses antitumor activity and is commonly used in cancer-related experimental research.

Cas No. 218137-86-1

Pack Size	Price	USA Stock	Global Stock
1 mg	$41	In Stock	-
2 mg	$59	6-8 weeks	6-8 weeks
5 mg	$98	In Stock	-
10 mg	$165	In Stock	-
25 mg	$332	6-8 weeks	6-8 weeks
50 mg	$530	6-8 weeks	6-8 weeks
100 mg	$840	6-8 weeks	6-8 weeks
1 mL x 10 mM (in DMSO)	$108	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:98.84%

Appearance:Solid

Color:White

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	C75 is a fatty acid synthase (FASN) inhibitor (IC50 = 35 μM in PC3 cells) with cell permeability and the ability to activate CPT1A. This compound possesses antitumor activity and is commonly used in cancer-related experimental research.
Targets & IC50	MCF-7 cells:27.3 μM, Fibroblast:63.2 μM, SKBR3 cells:19.8 μM, MDA-MB-231 cells:43.8 μM, MIAPaCa2 cells:21.8 μM, LNCaP cells:50 μM, PC3 cells:35 μM, HCT116 cells:46.4 μM, OVCAR-3 cells:21.9 μM
In vitro	Methods: The in vitro activity of C75 was validated using HeLa and CaSki cells. Cells were pretreated with 50 μM C75 for 1 hour, followed by wound healing, Transwell migration/invasion, and tube formation assays. Results: C75 significantly inhibited the migration, invasion, and lymphangiogenesis abilities of cervical cancer cells. [1]
In vivo	Methods: BALB/c nude mice were used to establish a cervical cancer lymph node metastasis model, with HeLa or CaSki cells inoculated into the footpad. C75 was administered via intraperitoneal injection at a dose of 10 mg/kg every other day for 2 weeks, with vehicle as control. Results: C75 treatment significantly suppressed popliteal lymph node volume and metastasis rate, and reduced lymphatic vessel density at the tumor site. [1] Methods: A 4T1 breast cancer-bearing Balb/c mouse model was used, with C75 administered via intraperitoneal injection at a dose of 10 mg/kg every 3 days for 17 consecutive days. Results: C75 monotherapy mildly inhibited tumor growth, while combination with CYH33 synergistically enhanced antitumor efficacy, increased FFA levels in tumor tissue, promoted CD8⁺ T cell infiltration, and reduced M2 macrophages. [2]
Synonyms	C-75

Chemical Properties

Molecular Weight	254.32
Formula	C₁₄H₂₂O₄
Cas No.	218137-86-1
Smiles	CCCCCCCCC1OC(=O)C(=C)C1C(O)=O
Relative Density.	1.08 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 75.6 mg/mL (297.26 mM), Sonication is recommended.

In Vivo Formulation

0.5% CMC-Na: 5 mg/mL (19.66 mM), Suspension.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9321 mL	19.6603 mL	39.3205 mL	196.6027 mL
5 mM	0.7864 mL	3.9321 mL	7.8641 mL	39.3205 mL
10 mM	0.3932 mL	1.9660 mL	3.9321 mL	19.6603 mL
20 mM	0.1966 mL	0.9830 mL	1.9660 mL	9.8301 mL
50 mM	0.0786 mL	0.3932 mL	0.7864 mL	3.9321 mL
100 mM	0.0393 mL	0.1966 mL	0.3932 mL	1.9660 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.