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Bradykinin (2-9)

Catalog No. TP1181 CAS 16875-11-9

Synonyms: Des-Arg1-bradykinin

Bradykinin (2-9) (Des-Arg1-bradykinin) is an amino-truncated peptide compound that is a metabolite of Bradykinin. It is formed by the cleavage action of Aminopeptidase P.

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Bradykinin (2-9), CAS 16875-11-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 44.00
2 mg	In stock	$ 63.00
5 mg	In stock	$ 97.00
10 mg	In stock	$ 168.00
25 mg	In stock	$ 283.00
50 mg	In stock	$ 422.00
100 mg	In stock	$ 613.00
1 mL * 10 mM (in DMSO)	In stock	$ 185.00

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Purity: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Bradykinin (2-9) (Des-Arg1-bradykinin) is an amino-truncated peptide compound that is a metabolite of Bradykinin. It is formed by the cleavage action of Aminopeptidase P.

In vitro

The Bradykinin peptide system, crucial for cardiovascular and renal functions, is examined using a highly sensitive amino terminal-directed radioimmunoassay combined with high-performance liquid chromatography. This method allows for the precise measurement of various Bradykinin peptides, including Bradykinin-(1-7), Bradykinin-(1-8), and Bradykinin-(1-9). An additional carboxy terminal-directed radioimmunoassay facilitates the characterization of these peptides in rat kidney and blood. The primary findings indicate that Bradykinin-(1-9) and Bradykinin-(1-7) are the most abundant in the kidney, with significantly lower concentrations of Bradykinin-(1-8) and Bradykinin-(4-9), while Bradykinin-(2-9) and Bradykinin-(3-9) are undetectable. Blood analysis shows very low levels of Bradykinin-(1-9), with other peptides falling below detection thresholds. Administration of the ACE inhibitor Perindopril significantly increases renal levels of Bradykinin-(1-8) and Bradykinin-(1-9), altering the Bradykinin-(1-7)/Bradykinin-(1-9) ratio. This radioimmunoassay approach is also effectively applied to heart, aorta, brown adipose tissue, adrenal, lung, and brain tissues, identifying similar abundance levels of Bradykinin-(1-7) and Bradykinin-(1-9), with Bradykinin-(1-8) present in lower amounts.

Synonyms	Des-Arg1-bradykinin
Molecular Weight	904.02
Formula	C44H61N11O10
CAS No.	16875-11-9

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mM

References and Literature

1. Campbell DJ, et al. Bradykinin peptides in kidney, blood, and other tissues of the rat. Hypertension. 1993 Feb;21(2):155-65.

Related compound libraries

This product is contained In the following compound libraries：

Peptide Compound Library GPCR Compound Library Bioactive Compounds Library Max Bioactive Compound Library NO PAINS Compound Library

Related Products

Related compounds with same targets

Safotibant ELN-441958 Bradykinin (acetate) Bradykinin [Des-Arg9]-Bradykinin acetate Des-Arg9-[Leu8]-Bradykinin acetate SSR240612 [Des-Arg9]-Bradykinin

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Keywords

Bradykinin (2-9) 16875-11-9 GPCR/G Protein Bradykinin Receptor Bradykinin (29) Bradykinin (2 9) Des-Arg1-bradykinin Bradykinin inhibit Inhibitor inhibitor

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