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Bisaramil hydrochloride

Catalog No. T26822 CAS 96480-44-3

Synonyms: RGH 2957, NK1556, RGH-2957, NK-1556, NK 1556, Bisaramil

Bisaramil, a Calcium Channel antagonist and Sodium Channel antagonist, is used potentially for the treatment of arrhythmia.

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Bisaramil hydrochloride, CAS 96480-44-3

Pack Size	Availability	Price/USD
5 mg	6-8 weeks	$ 970.00 $ 776.00
50 mg	6-8 weeks	$ 1,980.00 $ 1,584.00
100 mg	6-8 weeks	$ 2,500.00 $ 2,000.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Bisaramil, a calcium channel antagonist and sodium channel antagonist, is used potentially for the treatment of arrhythmia.

Synonyms	RGH 2957, NK1556, RGH-2957, NK-1556, NK 1556, Bisaramil
Molecular Weight	359.29
Formula	C17H24Cl2N2O2
CAS No.	96480-44-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Haruno A, Sugiyama A, Hashimoto K. Chronotropic, inotropic, dromotropic and coronary vasodilator effects of bisaramil, a new class I antiarrhythmic drug, assessed using canine isolated, blood-perfused heart preparations. Jpn J Pharmacol. 1999 Jul;80(3):267-70. PubMed PMID: 10461773. 2. Pugsley MK, Goldin AL. Effects of bisaramil, a novel class I antiarrhythmic agent, on heart, skeletal muscle and brain Na+ channels. Eur J Pharmacol. 1998 Jan 19;342(1):93-104. PubMed PMID: 9544797. 3. Paróczai M, Röth E, Kárpáti E. Bisaramil and antiarrhythmics as inhibitors of free radical generation. Pharmacol Res. 1997 Apr;35(4):279-85. PubMed PMID: 9264043. 4. Róth E, Lantos J, Temes G, Varga G, Paróczai M, Kárpáti E. Cardioprotection during heart ischemia-reperfusion. Acta Chir Hung. 1997;36(1-4):306-9. PubMed PMID: 9408384.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Bisaramil hydrochloride 96480-44-3 RGH 2957 NK1556 RGH-2957 NK-1556 NK 1556 Bisaramil inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.