Home Tools

Cart

Benzo[a]pyrene

Catalog No. T6985 CAS 50-32-8

Synonyms: 3,4-Benzopyrene

Benzo[a]pyrene (3,4-Benzopyrene) shows lung carcinogenicity in mice in a dose-dependent manner.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Benzo[a]pyrene, CAS 50-32-8

Pack Size	Availability	Price/USD
10 mg	In stock	$ 48.00
25 mg	In stock	$ 98.00
50 mg	In stock	$ 162.00
100 mg	In stock	$ 244.00
200 mg	In stock	$ 388.00
500 mg	In stock	$ 556.00
1 mL * 10 mM (in DMSO)	In stock	$ 54.00

Bulk Inquiry

Select Batch

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Benzo[a]pyrene (3,4-Benzopyrene) shows lung carcinogenicity in mice in a dose-dependent manner.
In vivo	lung tumorigenesis induced by Benzo[a]pyrene(B[a]P) was dose dependent in female A/J mice.?The incidence of hyperplasia values in females treated with 0.25, 0.50, and 1.0 mg B[a]P were significantly higher than in the vehicle-treated group.?The incidence of adenoma in females receiving 1.0 mg B[a]P was significantly higher than in the vehicle group.?The multiplicity of hyperplasia in females receiving 0.50 or 1.0 mg B[a]P was significantly higher than in the vehicle group.?The multiplicity of adenoma in the group treated with 1.0 mg was also significantly higher than in the vehicle group.?The incidences of hyperplasia and adenoma in female A/J mice were significantly increased by B[a]P in a dose-dependent manner.?Proliferative lesions in the lungs were classified as bronchiolar-alveolar hyperplasia or adenoma, and no malignant neoplasms (adenocarcinoma) were observed[1].
Animal Research	After a 1- or 2-week acclimatization period, 360 adult male A/J mice and 520 adult female A/J mice were used for the experiment.?Mice were allocated, using a body weight-based randomization process, to a total of 22 groups.?Briefly, each animal received a single intraperitoneal administration of one of the initiators, at one of the indicated doses, on day 1.?The animals were observed daily for clinical signs and mortality, and body weights were measured weekly.?Following an overnight fast at 26 weeks after dosing, all mice were anesthetized with sevoflurane and weighed.?They were then sacrificed by exsanguination from the abdominal aorta and caudal vena cava and subjected to necropsy[1].

Synonyms	3,4-Benzopyrene
Molecular Weight	252.31
Formula	C20H12
CAS No.	50-32-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 9.09 mg/mL (36.03 mM ), Sonication is recommended.

References and Literature

1. Saeko Onami,Chigusa Okubo, Asuka Iwanaga,et al.Dosimetry for lung tumorigenesis induced by urethane, 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and benzo[a]pyrene (B[a]P) in A/JJmsSlc mice[J].J Toxicol Pathol. 2017 Jul; 30(3): 209–216. 2. Yeo C D , Kim Y A , Lee H Y , et al. Roflumilast treatment inhibits lung carcinogenesis in benzo(a)pyrene-induced murine lung cancer model[J]. European Journal of Pharmacology, 2017:S0014299917304508.

Citations

1. Bao Z, Wang J, He M, et al. Benzo [a] pyrene inhibits myoblast differentiation through downregulating the Hsp70-K2-p38MAPK complex. Toxicology in Vitro. 2022: 105356

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Mouse Metabolite Compound Library Human Metabolite Library Bioactive Compounds Library Max

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below

Dosage

mg/kg

Average weight of animals

Dosing volume per animal

Number of animals

Step Two: Enter the in vivo formulation

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

Calculate Reset

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Calculator

Molarity Calculator

Dilution Calculator

Reconstitution Calculation

Molecular Weight Calculator

Mass

Concentration

Volume

Molecular Weight

Molarity Calculator allows you to calculate the

Mass of a compound required to prepare a solution of known volume and concentration
Volume of solution required to dissolve a compound of known mass to a desired concentration
Concentration of a solution resulting from a known mass of compound in a specific volume

See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

Concentration (Start)

Volume (Start)

Concentration (End)

Volume (End)

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Molecule Formula

Molecular Weight g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Benzo[a]pyrene 50-32-8 Others Inhibitor Endogenous Metabolite inhibit 3,4-Benzopyrene inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.