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BMS-488043

Catalog No. T30527 CAS 452296-83-2

Synonyms: CHEMBL238103, UNII-MKS21EJ435, BMS 043, BMS488043, BMS 488043

BMS-488043 is a novel and unique oral small molecule HIV fusion inhibitor that inhibits the attachment of Human Immunodeficiency Virus type 1 (HIV-1) to CD4(+) lymphocytes.BMS-488043 is used for the treatment of immune disorders, infections, and genitourinary disorders, and can be used in the study of HIV infect

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

BMS-488043, CAS 452296-83-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 138.00
5 mg	In stock	$ 340.00
10 mg	In stock	$ 510.00
25 mg	In stock	$ 828.00
50 mg	In stock	$ 1,150.00
100 mg	In stock	$ 1,550.00
500 mg	In stock	$ 2,970.00

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Purity: 99.72%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	CHEMBL238103, UNII-MKS21EJ435, BMS 043, BMS488043, BMS 488043
Molecular Weight	422.43
Formula	C22H22N4O5
CAS No.	452296-83-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Hanna GJ, et al. Antiviral activity, pharmacokinetics, and safety of BMS-488043, a novel oral small-molecule HIV-1 attachment inhibitor, in HIV-1-infected subjects. Antimicrob Agents Chemother. 2011;55(2):722-728. 2. Li L, et al. The investigations on HIV-1 gp120 bound with BMS-488043 by using docking and molecular dynamics simulations. J Mol Model. 2013;19(2):905-917. 3. Yang Z, et al. Utilization of in vitro Caco-2 permeability and liver microsomal half-life screens in discovering BMS-488043, a novel HIV-1 attachment inhibitor with improved pharmacokinetic properties. J Pharm Sci. 2010;99(4):2135-2152. 4. Zhou N, et al. In vivo patterns of resistance to the HIV attachment inhibitor BMS-488043. Antimicrob Agents Chemother. 2011;55(2):729-737.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Viral Compound Library Bioactive Compound Library Bioactive Compounds Library Max

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BMS-488043 452296-83-2 Microbiology/Virology Proteases/Proteasome HIV Protease CHEMBL 238103 UNII-MKS21EJ-435 CHEMBL238103 UNII-MKS21EJ435 BMS 043 UNII-MKS21EJ 435 CHEMBL-238103 BMS043 BMS488043 BMS-043 BMS 488043 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.