Shopping Cart

Your shopping cart is currently empty

BMS-488043

Name: BMS-488043
Brand: TargetMol
SKU: T30527
Price: 138 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T30527Cas No. 452296-83-2

Alias UNII-MKS21EJ435, CHEMBL238103, BMS488043, BMS 488043, BMS 043

BMS-488043 is a novel and unique oral small molecule HIV fusion inhibitor that inhibits the attachment of Human Immunodeficiency Virus type 1 (HIV-1) to CD4(+) lymphocytes.BMS-488043 is used for the treatment of immune disorders, infections, and genitourinary disorders, and can be used in the study of HIV infect

BMS-488043

Copy Product Info

😃Good

Purity: 99.95%

Catalog No. T30527Alias UNII-MKS21EJ435, CHEMBL238103, BMS488043, BMS 488043, BMS 043Cas No. 452296-83-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$138	In Stock	In Stock
5 mg	$340	In Stock	In Stock
10 mg	$510	In Stock	In Stock
25 mg	$828	In Stock	In Stock
50 mg	$1,150	In Stock	In Stock
100 mg	$1,550	-	In Stock
500 mg	$2,970	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.95%

Appearance:Solid

Color:Red

Resource Download

COA LCMS HNMR

Product Introduction

BMS-488043 AI Summary

BMS-488043 exhibits potent antiviral activity against various strains of HIV-1, including both R5-tropic and X4-tropic strains, with IC50 values as low as 0.88 nM and EC50 values ranging from 0.8 nM to 7131.0 nM. It shows effective inhibition of HIV-1 gp120/CD4 interactions, with an IC50 of 25.82 nM, and demonstrates protection against viral envelope infection in human cells. The compound also has low cytotoxicity in different cell lines, such as human U87 and HeLa cells, with CC50 values exceeding 40,000.0 nM to 300,000.0 nM. Pharmacokinetic studies reveal that BMS-488043 has high oral bioavailability in rats (90%), moderate oral bioavailability in dogs (57%), and monkeys (60%). It exhibits favorable pharmacokinetic properties including a high AUC of 2661.37 ng.hr.mL-1 and a Cmax of 1889.0 nM at a 5 mg/kg oral dose in rats. The compound also shows good permeability in human Caco-2 cells, low clearance rates of 13.0 mL/min/kg in rats, significant aqueous solubility in various pH buffer solutions, and reasonable metabolic stability in human liver microsomes with a half-life greater than 100.0 hours. In high-fat fed healthy humans, it achieves a plasma concentration (Cmax) of 9705.52 nM and an AUC of 21191.0 ng.hr.mL-1 after 800 mg oral administration, with a half-life of 14.0 hours. Overall, BMS-488043's potent antiviral efficacy, low cytotoxicity, and favorable pharmacokinetic profile make it a promising candidate for further development in antiviral drug research..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	BMS-488043 is a novel and unique oral small molecule HIV fusion inhibitor that inhibits the attachment of Human Immunodeficiency Virus type 1 (HIV-1) to CD4(+) lymphocytes.BMS-488043 is used for the treatment of immune disorders, infections, and genitourinary disorders, and can be used in the study of HIV infect
Synonyms	UNII-MKS21EJ435, CHEMBL238103, BMS488043, BMS 488043, BMS 043

Chemical Properties

Molecular Weight	422.43
Formula	C₂₂H₂₂N₄O₅
Cas No.	452296-83-2
Smiles	C(C(=O)N1CCN(C(=O)C2=CC=CC=C2)CC1)(=O)C=3C=4C(=C(OC)N=CC4OC)NC3
Relative Density.	1.363 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (118.36 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3673 mL	11.8363 mL	23.6726 mL	118.3628 mL
5 mM	0.4735 mL	2.3673 mL	4.7345 mL	23.6726 mL
10 mM	0.2367 mL	1.1836 mL	2.3673 mL	11.8363 mL
20 mM	0.1184 mL	0.5918 mL	1.1836 mL	5.9181 mL
50 mM	0.0473 mL	0.2367 mL	0.4735 mL	2.3673 mL
100 mM	0.0237 mL	0.1184 mL	0.2367 mL	1.1836 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc