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BI 99179

Catalog No. T14570 CAS 1291779-76-4

Synonyms: BI99179

BI99179 is a potent and selective type I <a href="/target/Fatty_Acid_Synthase" style="display: inline; color: #c13a36">Fatty Acid Synthase</a> (FAS) inhibitor with an IC50 of 79 nM and it exhibits significant exposure (both peripheral and central) upon oral administration in rats[1].

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BI 99179, CAS 1291779-76-4

Pack Size	Availability	Price/USD
5 mg	8-10 weeks	$ 970.00
50 mg	8-10 weeks	$ 1,980.00
100 mg	8-10 weeks	$ 2,500.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	BI99179 is a potent and selective type I fatty acid synthase (FAS) inhibitor with an IC50 of 79 nM and it exhibits significant exposure (both peripheral and central) upon oral administration in rats[1].
Targets&IC50	fas:79 nM
In vitro	BI 99179 is potent in the mouse hypothalamic N-42 cell with an IC50 of 0.6 μM and it shows no significant LDH release in the cytotoxicity assay up to 30 μM[1].
In vivo	BI 99179 has a super pharmacokinetic profile in male Han/Wistar rats (oral application of 4 mg/kg)with half life (t1/2) of 3.0 h[1].

Synonyms	BI99179
Molecular Weight	391.46
Formula	C23H25N3O3
CAS No.	1291779-76-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Kley JT, et al. Discovery of BI 99179, a potent and selective inhibitor of type I fatty acid synthase with central exposure.Bioorg Med Chem Lett. 2011 Oct 1;21(19):5924-7.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BI 99179 1291779-76-4 Metabolism Fatty Acid Synthase BI99179 Inhibitor inhibitor inhibit

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