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BBT594

Catalog No. T7418 CAS 882405-89-2

Synonyms: NVP-BBT594

BBT594(NVP-BBT594) is a potent inhibitor of receptor tyrosine kinase RET,Treatment of cancer.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

BBT594, CAS 882405-89-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 37.00
5 mg	In stock	$ 101.00
10 mg	In stock	$ 158.00
25 mg	In stock	$ 250.00
50 mg	In stock	$ 401.00
100 mg	In stock	$ 612.00
1 mL * 10 mM (in DMSO)	In stock	$ 126.00

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Purity: 96.56%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

BBT594(NVP-BBT594) is a potent inhibitor of receptor tyrosine kinase RET,Treatment of cancer.

Synonyms	NVP-BBT594
Molecular Weight	569.589
Formula	C28H30F3N7O3
CAS No.	882405-89-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 33 mg/mL (57.94 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Zhang Q , Shi C , Han L , et al. Inhibition of mTORC1/C2 signaling improves anti-leukemia efficacy of JAK/STAT blockade in CRLF2 rearranged and/or JAK driven Philadelphia chromosome–like acute B-cell lymphoblastic leukemia[J]. Oncotarget, 2018, 9(8). 2. Morandi A , Martin L A , Gao Q , et al. GDNF-RET Signaling in ER-Positive Breast Cancers Is a Key Determinant of Response and Resistance to Aromatase Inhibitors[J]. Cancer Research, 2013, 73(12):3783-3795.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Bioactive Compound Library Anti-Cancer Active Compound Library NO PAINS Compound Library Apoptosis Compound Library Tyrosine Kinase Inhibitor Library Inhibitor Library Kinase Inhibitor Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets

Pralsetinib Ilorasertib Regorafenib Hydrochloride BBT594 Compound TPX-0046 TPX-0046 ENMD-2076 TG-89

Dose Conversion

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BBT594 882405-89-2 Apoptosis Tyrosine Kinase/Adaptors c-RET RET Inhibitor BBT-594 NVP-BBT594 inhibit BBT 594 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.