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Ampicillin

Catalog No. T0814L CAS 69-53-4

Synonyms: Amcill, D-(-)-α-Aminobenzylpenicillin, Aminobenzylpenicillin, Ampicillin acid

Ampicillin (Aminobenzylpenicillin) is a semi-synthetic penicillin belonging to the β-lactam group of antibiotics. Ampicillin has bactericidal activity against a wide range of Gram-positive and Gram-negative bacteria.

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Ampicillin, CAS 69-53-4

Pack Size	Availability	Price/USD	Quantity
1 g	In stock	$ 42.00
1 mL * 10 mM (in DMSO)	In stock	$ 30.00

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Purity: 99.59%

Purity: 99.42%

Purity: 99.27%

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Description	Ampicillin (Aminobenzylpenicillin) is a semi-synthetic penicillin belonging to the β-lactam group of antibiotics. Ampicillin has bactericidal activity against a wide range of Gram-positive and Gram-negative bacteria.
In vitro	METHODS: E. coli was treated with Ampicillin (0.1-10 μG/mL) for 6 h. Growth was measured using a Fisher Electrophotometer. RESULTS: No differences in E. coli growth were observed at concentrations of 0, 0.1, and 1.0 μG. 2.5, 5, and 10 μG concentrations of Ampicillin inhibited E. coli growth. [1] METHODS: Pharyngeal cancer cells Detroit-562 were treated with Ampicillin (10-100 μM) for 72 h. Cell viability was measured by MTT. RESULTS: The Ampicillin-treated groups at concentrations of 10, 25 and 50 μM showed higher cell viability than the control cells, with values of 112%, 107% and 106%, respectively. At concentrations of 75 and 100 μM, there was a slight but not significant decrease in cell viability with values of approximately 95% and 94%, respectively. [2]
In vivo	METHODS: To test the neuroprotective mechanism in a mouse model of transient total forebrain ischemia, Ampicillin (200 mg/kg) was injected intraperitoneally into C57BL/6 mice once a day for five days, and forebrain ischemia was induced 24 h after the last injection. RESULTS: Pretreatment with Ampicillin significantly attenuated neuronal damage in the CA1 subregion of the hippocampus, and Ampicillin may provide neuroprotection against cerebral ischemia/reperfusion injury by inducing GLT-1 protein and inhibiting MMP activity in the hippocampus of mice. [3] METHODS: To study the in vivo activity, Ampicillin (10-100 mg/kg) was administered by gavage to C57BL/6 mice once daily for two days. RESULTS: Exposure of mice to Ampicillin induced anxiety and colitis, and increased Aspergillus flora in the gut microbiota. [4]

Synonyms	Amcill, D-(-)-α-Aminobenzylpenicillin, Aminobenzylpenicillin, Ampicillin acid
Molecular Weight	349.4
Formula	C16H19N3O4S
CAS No.	69-53-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 22.5 mg/mL (64.39 mM)

References and Literature

1. Chopra SL, et al. Effect of Ampicillin on E. Coli of Swine Origin. Can J Comp Med Vet Sci. 1963 Sep;27(9):223-7. 2. Pancu DF, et al. Assessment of the In Vitro Cytotoxic Profile of Two Broad-Spectrum Antibiotics-Tetracycline and Ampicillin-On Pharyngeal Carcinoma Cells. Medicina (Kaunas). 2022 Sep 16;58(9):1289. 3. Lee KE, et al. The neuroprotective mechanism of ampicillin in a mouse model of transient forebrain ischemia. Korean J Physiol Pharmacol. 2016 Mar;20(2):185-92. 4. Jang HM, et al. Evidence for interplay among antibacterial-induced gut microbiota disturbance, neuro-inflammation, and anxiety in mice. Mucosal Immunol. 2018 Sep;11(5):1386-1397.

Citations

1. Yue Y, Xu J, Li Y, et al. Antigen-bearing outer membrane vesicles as tumour vaccines produced in situ by ingested genetically engineered bacteria. Nature Biomedical Engineering. 2022: 1-12 2. Shan T, Huang Y, Zhao Z, et al. Ketogenic diet restrains herpes simplex encephalitis via gut microbes. Microbes and Infection. 2022: 105061. 3. Li F, Wang Y, Song X, et al. The intestinal microbial metabolite nicotinamide n-oxide prevents herpes simplex encephalitis via activating mitophagy in microglia. Gut Microbes. 2022, 14(1): 2096989

Related compound libraries

This product is contained In the following compound libraries：

Microbial Natural Product Library Drug Repurposing Compound Library Bioactive Compound Library Human Metabolite Library Clinical Compound Library Pediatric Drug Library Natural Product Library for HTS Bioactive Compounds Library Max Anti-infective Natural Product Library Natural Product Library

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Keywords

Ampicillin 69-53-4 Microbiology/Virology Antibiotic Antibacterial Amcill D-(-)-α-Aminobenzylpenicillin inhibit Inhibitor Aminobenzylpenicillin D-alpha-Aminobenzylpenicillin D-α-Aminobenzylpenicillin Bacterial Ampicillin acid D-a-Aminobenzylpenicillin inhibitor

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