Powder: -20°C for 3 years
In solvent: -80°C for 2 years
AZD5582 is an inhibitor of IAPs, which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. It induces <a href="/pathway/Apoptosis" style="display: inline; color: #c13a36">Apoptosis</a>.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In Stock (ship within 1 week) | $ 100.00 | |
10 mg | In Stock (ship within 1 week) | $ 150.00 | |
50 mg | In Stock (ship within 1 week) | $ 448.00 | |
1 mL * 10 mM (in DMSO) | In Stock (ship within 1 week) | $ 227.00 |
Description | AZD5582 is an inhibitor of IAPs, which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. It induces apoptosis. |
Targets&IC50 | cIAP2:21 nM (IC50), XIAP:15 nM (IC50), cIAP1:15 nM (IC50) |
In vitro | AZD5582 (20 nM; 48 hours) inhibited cell viability by cooperation with IFNγ or viral double-stranded RNA (dsRNA) in H1975 NSCLC cells[2]. AZD5582 (20 nM; 48 hours) involves in apoptosis due to induction of cell death and active caspase-3/ -8 activities by AZD5582 and IFNγ co-treatment in HCC827 NSCLC cells[2]. AZD5582 (20 nM; 17 or 25 hours) down-regulates cIAP-1, activates RIPK1( upstream regulator of caspase-8), and triggers the activation of extrinsic (caspase-8) and intrinsic (caspase-9) apoptosis pathways, causing the cleavage of caspase-3 and caspase-7[2]. |
In vivo | AZD5582 (intravenous injection; 0.1-3.0 mg/kg; once a week; 2 weeks) causes degradation of cIAP1 and caspase 3 cleavage in tumor cells, and after a two-week treatment, the tumors largely resolved. When the mice are given a medium dose (0.5 mg/kg) of AZD5582, cIAP1 degrades after administration, but it takes a while time to reach apoptosis-inducing effect[1]. |
Molecular Weight | 1015.29 |
Formula | C58H78N8O8 |
CAS No. | 1258392-53-8 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 66.25 mg/mL (65.25 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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AZD5582 1258392-53-8 Apoptosis IAP AZD 5582 inhibit AZD-5582 Inhibitor inhibitor