Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AZD5582 is an inhibitor of IAPs, which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. It induces apoptosis.
Pack Size | Availability | Price/USD | Quantity |
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50 mg | 5 days | Inquiry | |
100 mg | 5 days | Inquiry |
Description | AZD5582 is an inhibitor of IAPs, which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. It induces apoptosis. |
Targets&IC50 | CIAP2:21 nM (IC50), XIAP:15 nM (IC50), CIAP1:15 nM (IC50) |
In vitro | AZD5582 (20 nM; 48 hours) inhibited cell viability by cooperation with IFNγ or viral double-stranded RNA (dsRNA) in H1975 NSCLC cells[2]. AZD5582 (20 nM; 48 hours) involves in apoptosis due to induction of cell death and active caspase-3/ -8 activities by AZD5582 and IFNγ co-treatment in HCC827 NSCLC cells[2]. AZD5582 (20 nM; 17 or 25 hours) down-regulates cIAP-1, activates RIPK1( upstream regulator of caspase-8), and triggers the activation of extrinsic (caspase-8) and intrinsic (caspase-9) apoptosis pathways, causing the cleavage of caspase-3 and caspase-7[2]. |
In vivo | AZD5582 (intravenous injection; 0.1-3.0 mg/kg; once a week; 2 weeks) causes degradation of cIAP1 and caspase 3 cleavage in tumor cells, and after a two-week treatment, the tumors largely resolved. When the mice are given a medium dose (0.5 mg/kg) of AZD5582, cIAP1 degrades after administration, but it takes a while time to reach apoptosis-inducing effect[1]. |
Molecular Weight | 1015.29 |
Formula | C58H78N8O8 |
CAS No. | 1258392-53-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 66.25 mg/mL (65.25 mM)
You can also refer to dose conversion for different animals. More
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AZD5582 1258392-53-8 Apoptosis IAP inhibit Inhibitor AZD-5582 AZD 5582 inhibitor