Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme (IC50=13 nM). At high doses, AY 9944 inhibits also in cultured embryos sterol Δ7-Δ8 isomerase, which causes the accumulation of cholest-8-en-3β-ol[1][2][3]. AY 9944 causes hypocholesterolemia and accumulation of 7DHC.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 639.00 | |
5 mg | In stock | $ 970.00 |
Description | AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme (IC50=13 nM). At high doses, AY 9944 inhibits also in cultured embryos sterol Δ7-Δ8 isomerase, which causes the accumulation of cholest-8-en-3β-ol[1][2][3]. AY 9944 causes hypocholesterolemia and accumulation of 7DHC. |
Targets&IC50 | DHCR7:13 nM |
Molecular Weight | 464.3 |
Formula | C22H30Cl4N2 |
CAS No. | 366-93-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 4.64 mg/mL (10 mM)
DMSO: 4.64 mg/mL (10 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
AY 9944 366-93-8 Others 7DHC AY-9944 hypocholesterolemia inhibit cholesterol Inhibitor isomerase Δ7-Δ8 accumulation reductase AY9944 biosynthesis inhibitor