Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ADU-S100 ammonium salt (ML RR-S2 CDA ammonium salt) is an activator of stimulator of interferon genes (STING). ADU-S100 ammonium salt leads to potent and systemic tumor regression and immunity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 159.00 | |
5 mg | In stock | Inquiry | |
1 mL * 10 mM (in DMSO) | In stock | Inquiry |
Description | ADU-S100 ammonium salt (ML RR-S2 CDA ammonium salt) is an activator of stimulator of interferon genes (STING). ADU-S100 ammonium salt leads to potent and systemic tumor regression and immunity. |
In vitro | ADU-S100 ammonium salt induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C. ADU-S100 ammonium salt is also found to induce aggregation of STING and induce phosphorylation of TBK1 and IRF3 in mouse bone marrow macrophage. ADU-S100 ammonium salt induces significantly higher levels of IFN-α compared to ML cGAMP[1]. |
In vivo | IT injection of ADU-S100 ammonium salt into one tumor in BALB/c mice bearing bilateral CT26 or 4T1 tumors also demonstrated significant regression of the contralateral, untreated tumor. IT injection with ADU-S100 ammonium salt eradicates multiple tumor types and primes an effective systemic CD8+ T cell immune response that significantly inhibits the growth of distal, untreated lesions[1]. |
Synonyms | ML RR-S2 CDA ammonium salt, MIW815 ammonium salt |
Molecular Weight | 724.6 |
Formula | C20H30N12O10P2S2 |
CAS No. | 1638750-96-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 5 mg/mL (6.90 mM), Sonication is recommended.
DMSO: 12 mg/mL (16.58 mM), Sonication and heating are recommended.
You can also refer to dose conversion for different animals. More
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ADU-S100 ammonium salt 1638750-96-5 Immunology/Inflammation STING inhibit ADU S100 ammonium salt TMEM173 ML RR-S2 CDA ammonium salt MIW815 Inhibitor MIW-815 ML RR-S2 CDA ammonium MIW815 ammonium Stimulator of Interferon Genes MIW815 ammonium salt MITA MPYS ERIS ADU-S100 ML RR-S2 CDA MIW 815 ADU-S100 ammonium ADUS100 ammonium salt inhibitor