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A 779 TFA(159432-28-7 free base)

Catalog No. T7616L CAS T7616L

Synonyms: A 779 3TFA(159432-28-7(free base)),

A 779(3TFA) is a potent antagonist of angiotensin-(1-7) receptor

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A 779 TFA(159432-28-7 free base), CAS T7616L

Pack Size	Availability	Price/USD
1 mg	In stock	50.00
5 mg	In stock	62.00
10 mg	In stock	92.00
25 mg	In stock	167.00
50 mg	In stock	250.00
100 mg	In stock	375.00

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Purity 100.00%

HNMR LCMS COA

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Biological Description

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Storage & Solubility Information

Description

A 779(3TFA) is a potent antagonist of angiotensin-(1-7) receptor

Cell Research

HUVECs were cultured in vitro and divided into six groups: the control group (normal medium), the ox-LDL group(treated with 75 mg/L ox-LDL), the ox-LDL+ Ang-(1-7) group (1 μmol/L Ang-(1-7) pretreated for 30 minutes, then intervened with 75 mg/L ox-LDL), the ox-LDL+ Ang-(1-7)+ A-779 group(1 μmol/L A-779 (Mas receptor) pretreated for 30 minutes, 1 μmol/L Ang-(1-7) pretreated for 30 minutes, then intervened with 75 mg/L ox-LDL), the ox-LDL+ A-779 group (1 μmol/L A-779 pretreated for 30 minutes, then intervened with 75 mg/L ox-LDL), the ox-LDL+ HTA125 group (10 μg/L HTA125 (TLR4-blocking antibody) pretreated for 30 minutes, then intervened with 75 mg/L ox-LDL ). The corresponding index was detected after 24 hours after intervention. Apoptosis of cells were detected by Annexin V-FITC/PI double staining flow cytometry and transferase-mediated deoxyuridine triphosphate-biotin nick end labeling (TUNEL). The generation of reactive oxygen species (ROS), products in oxidative stress, were detected by DCFH-DA staining. The mRNA and protein expression levels of NADPH oxidase 4(NOX4) and TLR4 were detected by real-time reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting analysis respectively[1].

Cell lines:

Synonyms	A 779 3TFA(159432-28-7(free base)) ,
Purity	100.00%
Molecular Weight	987.01
Formula	C41H61F3N12O13
CAS No.	T7616L

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 6 months

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Yan W F , Xue J J , Yang H Y , et al. [Effects and related mechanism of angiotensin-(1-7) on Toll-like receptor 4-mediated oxidative stress in human umbilical vein endothelial cells].[J]. Zhonghua Xin Xue Guan Bing Za Zhi, 2017, 45(3):223. 2. Abuohashish H M , Ahmed M M , Sabry D , et al. ACE-2/Ang1-7/Mas cascade mediates ACE inhibitor, captopril, protective effects in estrogen-deficient osteoporotic rats[J]. Biomedicine & Pharmacotherapy, 2017, 92:58-68.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Inhibitor Library Endocrinology-Hormone Compound Library

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